Magnesium in PDB 9mhh: PI3KC3-C1 in Complex with RAB1A. VPS34 Kinase Domain Active Conformation

All present enzymatic activity of PI3KC3-C1 in Complex with RAB1A. VPS34 Kinase Domain Active Conformation:
2.7.1.137; 2.7.11.1; 3.6.5.2;

The binding sites of Magnesium atom in the PI3KC3-C1 in Complex with RAB1A. VPS34 Kinase Domain Active Conformation (pdb code 9mhh). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the PI3KC3-C1 in Complex with RAB1A. VPS34 Kinase Domain Active Conformation, PDB code: 9mhh:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the PI3KC3-C1 in Complex with RAB1A. VPS34 Kinase Domain Active Conformation


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of PI3KC3-C1 in Complex with RAB1A. VPS34 Kinase Domain Active Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg2002 b:195.0 occ:1.00 PA A:GTP2001 1.7 122.3 1.0 O2A A:GTP2001 1.8 122.3 1.0 O3A A:GTP2001 1.9 122.3 1.0 O1A A:GTP2001 2.0 122.3 1.0 PB A:GTP2001 2.0 122.3 1.0 O3B A:GTP2001 2.1 122.3 1.0 O1G A:GTP2001 2.2 122.3 1.0 O1B A:GTP2001 2.3 122.3 1.0 PG A:GTP2001 2.5 122.3 1.0 O5' A:GTP2001 3.3 122.3 1.0 O3G A:GTP2001 3.4 122.3 1.0 O2B A:GTP2001 3.5 122.3 1.0 O2G A:GTP2001 3.8 122.3 1.0 C5' A:GTP2001 4.3 122.3 1.0 C3' A:GTP2001 4.9 122.3 1.0 O A:GLU152 5.0 103.8 1.0

Magnesium binding site 2 out of 2 in the PI3KC3-C1 in Complex with RAB1A. VPS34 Kinase Domain Active Conformation


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of PI3KC3-C1 in Complex with RAB1A. VPS34 Kinase Domain Active Conformation within 5.0Å range: probe atom residue distance (Å) B Occ E:Mg1001 b:160.8 occ:1.00 O1A E:GTP1002 1.4 148.2 1.0 O2B E:GTP1002 1.5 148.2 1.0 PA E:GTP1002 1.7 148.2 1.0 N E:SER25 1.9 151.1 1.0 O2A E:GTP1002 2.0 148.2 1.0 PB E:GTP1002 2.2 148.2 1.0 O3A E:GTP1002 2.2 148.2 1.0 CA E:SER25 2.7 151.1 1.0 C E:LYS24 3.0 157.3 1.0 N E:LYS24 3.0 157.3 1.0 O3B E:GTP1002 3.2 148.2 1.0 O3G E:GTP1002 3.2 148.2 1.0 O5' E:GTP1002 3.3 148.2 1.0 CA E:LYS24 3.3 157.3 1.0 O1B E:GTP1002 3.4 148.2 1.0 C E:GLY23 3.5 153.5 1.0 C E:SER25 3.8 151.1 1.0 N E:CYS26 3.8 136.1 1.0 PG E:GTP1002 3.9 148.2 1.0 O E:LYS24 4.1 157.3 1.0 CA E:GLY23 4.1 153.5 1.0 O E:GLY23 4.1 153.5 1.0 C5' E:GTP1002 4.1 148.2 1.0 N E:GLY23 4.4 153.5 1.0 O2G E:GTP1002 4.5 148.2 1.0 O E:SER25 4.9 151.1 1.0

A.S.I.Cook, M.Chen, T.N.Ngyuen, A.Claveras-Cabezudo, G.Khuu, S.Rao, S.N.Garcia, M.Yang, A.T.Iavarone, X.Ren, M.Lazarou, G.Hummer, J.H.Hurley. Structural Pathway For Class III Pi 3-Kinase Activation By the Myristoylated Gtpbinding Pseudokinase VPS15 To Be Published.