Magnesium in PDB 1qzr: Crystal Structure of the Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (Dexrazoxane)

All present enzymatic activity of Crystal Structure of the Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (Dexrazoxane):
5.99.1.3;

The structure of Crystal Structure of the Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (Dexrazoxane), PDB code: 1qzr was solved by S.Classen, S.Olland, J.M.Berger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.18 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	58.553, 71.444, 215.724, 90.00, 90.00, 90.00
R / Rfree (%)	19.6 / 23.7

The binding sites of Magnesium atom in the Crystal Structure of the Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (Dexrazoxane) (pdb code 1qzr). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of the Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (Dexrazoxane), PDB code: 1qzr:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crystal Structure of the Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (Dexrazoxane)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (Dexrazoxane) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg904 b:23.2 occ:1.00 O1B A:ANP902 2.0 22.0 1.0 O1A A:ANP902 2.1 20.5 1.0 O2G A:ANP902 2.1 21.6 1.0 O A:HOH905 2.1 21.4 1.0 OD1 A:ASN70 2.1 12.9 1.0 O A:HOH937 2.2 20.0 1.0 PB A:ANP902 3.0 22.1 1.0 CG A:ASN70 3.1 13.4 1.0 PA A:ANP902 3.2 22.2 1.0 PG A:ANP902 3.3 24.0 1.0 O3A A:ANP902 3.3 21.6 1.0 ND2 A:ASN70 3.5 14.3 1.0 N3B A:ANP902 3.5 21.9 1.0 O A:HOH930 3.8 23.7 1.0 O5' A:ANP902 3.9 23.2 1.0 O A:HOH1182 4.1 98.5 1.0 O1G A:ANP902 4.2 22.0 1.0 OE1 A:GLU66 4.2 26.0 1.0 CA A:GLY140 4.3 18.9 1.0 O2B A:ANP902 4.3 22.1 1.0 O2A A:ANP902 4.3 22.0 1.0 O3G A:ANP902 4.4 23.9 1.0 CA A:GLY145 4.4 16.8 1.0 O A:GLU66 4.5 16.1 1.0 CB A:ASN70 4.5 14.2 1.0 N A:GLY145 4.7 16.2 1.0 OD2 A:ASP73 4.7 25.0 1.0 N A:ALA146 4.8 16.9 1.0 CA A:ASN70 4.8 15.0 1.0 N A:ASN70 4.9 15.1 1.0

Magnesium binding site 2 out of 2 in the Crystal Structure of the Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (Dexrazoxane)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of the Atpase Region of Saccharomyces Cerevisiae Topoisomerase II Bound to Icrf-187 (Dexrazoxane) within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg905 b:25.8 occ:1.00 O1B B:ANP903 2.0 26.7 1.0 O2G B:ANP903 2.0 24.1 1.0 O1A B:ANP903 2.1 27.3 1.0 O B:HOH910 2.1 19.7 1.0 O B:HOH911 2.1 28.2 1.0 OD1 B:ASN70 2.2 16.0 1.0 PB B:ANP903 3.0 26.8 1.0 CG B:ASN70 3.1 18.7 1.0 PA B:ANP903 3.2 26.5 1.0 PG B:ANP903 3.3 24.1 1.0 O3A B:ANP903 3.4 28.1 1.0 ND2 B:ASN70 3.5 16.3 1.0 N3B B:ANP903 3.6 27.2 1.0 O B:HOH931 3.9 28.7 1.0 O5' B:ANP903 4.0 29.9 1.0 OE1 B:GLU66 4.2 27.6 1.0 O1G B:ANP903 4.2 24.3 1.0 O3G B:ANP903 4.3 27.0 1.0 CA B:GLY140 4.3 21.6 1.0 O2B B:ANP903 4.3 26.9 1.0 O2A B:ANP903 4.3 25.8 1.0 CA B:GLY145 4.4 17.6 1.0 O B:GLU66 4.4 18.8 1.0 CB B:ASN70 4.5 18.2 1.0 N B:GLY145 4.6 18.6 1.0 NZ B:LYS367 4.7 27.9 1.0 N B:ALA146 4.8 17.2 1.0 CA B:ASN70 4.8 18.7 1.0 OD2 B:ASP73 4.8 26.0 1.0 C B:GLY145 5.0 17.4 1.0

S.Classen, S.Olland, J.M.Berger. Structure of the Topoisomerase II Atpase Region and Its Mechanism of Inhibition By the Chemotherapeutic Agent Icrf-187 Proc.Natl.Acad.Sci.Usa V. 100 10629 2003.
ISSN: ISSN 0027-8424
PubMed: 12963818
DOI: 10.1073/PNAS.1832879100