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Magnesium in PDB 2pz5: Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome

Enzymatic activity of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome

All present enzymatic activity of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome, PDB code: 2pz5 was solved by H.Chen, M.Mohammadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.40
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 105.043, 114.474, 64.347, 90.00, 90.00, 90.00
R / Rfree (%) 21.4 / 25.4

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome (pdb code 2pz5). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome, PDB code: 2pz5:
Jump to Magnesium binding site number: 1; 2; 3; 4;

Magnesium binding site 1 out of 4 in 2pz5

Go back to Magnesium Binding Sites List in 2pz5
Magnesium binding site 1 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg301

b:2.0
occ:1.00
 OD2 A:ASP644 2.2 22.6 1.0
ND2 A:ASN631 2.2 12.3 1.0
O1A A:ACP300 2.2 17.0 1.0
O A:HOH64 2.4 26.0 1.0
O3G A:ACP300 2.4 14.9 1.0
O A:HOH11 2.4 18.6 1.0
CG A:ASP644 3.3 21.9 1.0
CG A:ASN631 3.3 12.6 1.0
PG A:ACP300 3.4 17.3 1.0
PA A:ACP300 3.5 18.7 1.0
OD1 A:ASN631 3.6 12.1 1.0
O2G A:ACP300 3.6 14.1 1.0
CB A:ASP644 3.7 20.0 1.0
O3A A:ACP300 3.8 16.6 1.0
MG A:MG302 4.2 2.0 1.0
O A:HOH155 4.2 33.2 1.0
C3B A:ACP300 4.3 16.1 1.0
O A:HOH82 4.3 21.6 1.0
O A:HOH121 4.3 25.0 1.0
O1B A:ACP300 4.3 13.1 1.0
OD1 A:ASP644 4.3 24.2 1.0
O A:ARG630 4.4 15.1 1.0
PB A:ACP300 4.4 16.7 1.0
O2A A:ACP300 4.4 16.3 1.0
O5' A:ACP300 4.5 17.2 1.0
OD1 A:ASP626 4.6 13.7 1.0
CB A:ASN631 4.6 12.0 1.0
NE A:ARG630 4.6 24.3 1.0
O1G A:ACP300 4.6 18.1 1.0
C5' A:ACP300 4.7 18.7 1.0
CA A:ASN631 4.8 12.4 1.0
C A:ARG630 4.9 14.7 1.0

Magnesium binding site 2 out of 4 in 2pz5

Go back to Magnesium Binding Sites List in 2pz5
Magnesium binding site 2 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg302

b:2.0
occ:1.00
 O1B A:ACP300 2.2 13.1 1.0
O2G A:ACP300 2.3 14.1 1.0
O A:HOH65 2.4 22.9 1.0
O A:HOH2 2.4 32.2 1.0
OD1 A:ASP644 2.5 24.2 1.0
OD2 A:ASP644 2.6 22.6 1.0
CG A:ASP644 2.9 21.9 1.0
PB A:ACP300 3.4 16.7 1.0
PG A:ACP300 3.4 17.3 1.0
C3B A:ACP300 3.6 16.1 1.0
O A:HOH14 3.8 27.0 1.0
O3G A:ACP300 4.1 14.9 1.0
O A:HOH82 4.1 21.6 1.0
MG A:MG301 4.2 2.0 1.0
NZ A:LYS517 4.3 20.4 1.0
O3A A:ACP300 4.3 16.6 1.0
CA A:GLY646 4.3 16.7 1.0
O A:HOH51 4.4 19.9 1.0
CB A:ASP644 4.4 20.0 1.0
O2B A:ACP300 4.6 15.0 1.0
O1G A:ACP300 4.6 18.1 1.0
N A:GLY646 4.6 16.7 1.0
O1A A:ACP300 4.7 17.0 1.0
O A:HOH11 4.7 18.6 1.0
PA A:ACP300 4.8 18.7 1.0
OD1 A:ASP626 4.8 13.7 1.0
O2A A:ACP300 4.8 16.3 1.0

Magnesium binding site 3 out of 4 in 2pz5

Go back to Magnesium Binding Sites List in 2pz5
Magnesium binding site 3 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg301

b:2.0
occ:1.00
 O2G B:ACP300 2.2 17.9 1.0
OD2 B:ASP644 2.3 13.7 1.0
O2A B:ACP300 2.3 13.8 1.0
ND2 B:ASN631 2.3 7.7 1.0
O B:HOH78 2.3 25.2 1.0
O B:HOH91 2.5 23.4 1.0
CG B:ASP644 3.3 13.3 1.0
PG B:ACP300 3.4 16.9 1.0
CG B:ASN631 3.4 9.3 1.0
PA B:ACP300 3.5 12.4 1.0
O3A B:ACP300 3.6 12.9 1.0
O1G B:ACP300 3.6 18.2 1.0
CB B:ASP644 3.7 12.8 1.0
OD1 B:ASN631 3.8 10.3 1.0
MG B:MG302 4.1 2.0 1.0
O B:HOH145 4.2 17.5 1.0
O1B B:ACP300 4.2 14.0 1.0
C3B B:ACP300 4.2 15.9 1.0
PB B:ACP300 4.3 13.9 1.0
OD1 B:ASP644 4.3 13.1 1.0
O B:ARG630 4.4 11.0 1.0
O5' B:ACP300 4.5 15.4 1.0
O1A B:ACP300 4.5 13.1 1.0
O3G B:ACP300 4.5 18.9 1.0
CB B:ASN631 4.7 10.5 1.0
C5' B:ACP300 4.7 15.5 1.0
NE B:ARG630 4.8 22.2 1.0
OD1 B:ASP626 4.8 13.1 1.0
CA B:ASN631 4.9 10.3 1.0

Magnesium binding site 4 out of 4 in 2pz5

Go back to Magnesium Binding Sites List in 2pz5
Magnesium binding site 4 out of 4 in the Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Crystal Structure of Fgf Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible For Pfeiffer Syndrome within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg302

b:2.0
occ:1.00
 O1B B:ACP300 2.3 14.0 1.0
O1G B:ACP300 2.3 18.2 1.0
O B:HOH79 2.3 23.2 1.0
O B:HOH75 2.4 22.0 1.0
OD1 B:ASP644 2.4 13.1 1.0
OD2 B:ASP644 2.5 13.7 1.0
CG B:ASP644 2.8 13.3 1.0
PG B:ACP300 3.4 16.9 1.0
PB B:ACP300 3.4 13.9 1.0
C3B B:ACP300 3.6 15.9 1.0
O B:HOH66 3.8 18.7 1.0
O2G B:ACP300 3.9 17.9 1.0
O B:HOH145 4.0 17.5 1.0
MG B:MG301 4.1 2.0 1.0
O3A B:ACP300 4.2 12.9 1.0
CB B:ASP644 4.3 12.8 1.0
NZ B:LYS517 4.3 16.8 1.0
CA B:GLY646 4.4 13.7 1.0
O B:HOH70 4.4 26.3 1.0
O2B B:ACP300 4.6 13.8 1.0
O2A B:ACP300 4.7 13.8 1.0
O3G B:ACP300 4.7 18.9 1.0
N B:GLY646 4.7 13.2 1.0
PA B:ACP300 4.8 12.4 1.0
O B:HOH91 4.9 23.4 1.0
O1A B:ACP300 4.9 13.1 1.0
OE1 B:GLU534 4.9 22.6 1.0

Reference:

H.Chen, J.Ma, W.Li, A.V.Eliseenkova, C.Xu, T.A.Neubert, W.T.Miller, M.Mohammadi. A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases. Mol.Cell V. 27 717 2007.
ISSN: ISSN 1097-2765
PubMed: 17803937
DOI: 10.1016/J.MOLCEL.2007.06.028
Page generated: Sun Aug 10 13:05:09 2025

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