Magnesium in PDB 2zej: Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase

All present enzymatic activity of Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase:
2.7.11.1;

The structure of Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase, PDB code: 2zej was solved by J.Deng, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.80 / 2.00
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	44.438, 44.404, 53.681, 81.51, 69.00, 78.71
R / Rfree (%)	19.9 / 25.3

The binding sites of Magnesium atom in the Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase (pdb code 2zej). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase, PDB code: 2zej:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg2 b:26.6 occ:1.00 O3B A:GDP1 2.0 18.8 1.0 O A:HOH200 2.0 20.4 1.0 OG1 A:THR1348 2.1 27.0 1.0 O A:HOH202 2.1 23.7 1.0 O A:HOH104 2.2 18.9 1.0 O A:HOH201 2.2 22.1 1.0 CB A:THR1348 3.1 26.7 1.0 PB A:GDP1 3.3 19.7 1.0 O2B A:GDP1 3.5 17.9 1.0 O A:HOH11 3.9 29.7 1.0 N A:THR1348 4.0 27.0 1.0 OD2 A:ASP1394 4.1 35.8 1.0 O2A A:GDP1 4.1 20.3 1.0 CA A:THR1348 4.1 27.6 1.0 CG2 A:THR1348 4.1 27.5 1.0 O3A A:GDP1 4.3 22.5 1.0 O1B A:GDP1 4.3 18.7 1.0 OG1 A:THR1368 4.3 40.4 1.0 OD1 A:ASP1394 4.4 33.3 1.0 CB A:THR1368 4.4 41.4 1.0 PA A:GDP1 4.5 24.2 1.0 CG2 A:THR1368 4.6 40.7 1.0 CG A:ASP1394 4.6 33.5 1.0 NZ A:LYS1347 4.7 26.4 1.0 O1A A:GDP1 4.8 21.7 1.0 CB A:LYS1347 4.9 26.6 1.0 CA A:ALA1396 4.9 31.3 1.0 O A:HOH22 4.9 23.7 1.0

Magnesium binding site 2 out of 2 in the Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1 b:25.1 occ:1.00 O B:HOH1519 2.0 21.8 1.0 O3B B:GDP2 2.1 18.3 1.0 OG1 B:THR1348 2.1 28.3 1.0 O B:HOH1517 2.2 25.0 1.0 O B:HOH1518 2.2 21.2 1.0 O B:HOH1569 2.3 24.0 1.0 CB B:THR1348 3.3 24.7 1.0 PB B:GDP2 3.3 20.2 1.0 O2B B:GDP2 3.5 21.0 1.0 O B:HOH1523 4.0 30.6 1.0 N B:THR1348 4.0 25.7 1.0 O2A B:GDP2 4.1 19.1 1.0 OG1 B:THR1368 4.1 37.4 1.0 CA B:THR1348 4.2 26.1 1.0 OD2 B:ASP1394 4.2 39.4 1.0 O1B B:GDP2 4.3 19.1 1.0 NZ B:LYS1347 4.3 25.6 1.0 CG2 B:THR1348 4.3 25.7 1.0 CB B:THR1368 4.3 39.9 1.0 O3A B:GDP2 4.3 22.4 1.0 OD1 B:ASP1394 4.4 35.6 1.0 PA B:GDP2 4.5 20.9 1.0 CG2 B:THR1368 4.5 36.8 1.0 O1A B:GDP2 4.6 21.0 1.0 CA B:ALA1396 4.7 32.3 1.0 CG B:ASP1394 4.7 34.0 1.0 O B:HOH1570 4.8 39.8 1.0 O B:HOH1522 4.9 25.4 1.0 CB B:LYS1347 4.9 25.6 1.0 CB B:ALA1396 5.0 32.3 1.0

J.Deng, P.A.Lewis, E.Greggio, E.Sluch, A.Beilina, M.R.Cookson. Structure of the Roc Domain From the Parkinson'S Disease-Associated Leucine-Rich Repeat Kinase 2 Reveals A Dimeric Gtpase Proc.Natl.Acad.Sci.Usa V. 105 1499 2008.
ISSN: ISSN 0027-8424
PubMed: 18230735
DOI: 10.1073/PNAS.0709098105