Magnesium »
PDB 3jay-3jwr »
3jsm »
Magnesium in PDB 3jsm: K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
Enzymatic activity of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
All present enzymatic activity of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate:
2.7.7.49;
2.7.7.49;
Protein crystallography data
The structure of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate, PDB code: 3jsm
was solved by
K.Das,
E.Arnold,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.17 / 3.00 |
| Space group | P 31 1 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 170.310, 170.310, 155.440, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 25.2 / 28.5 |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
(pdb code 3jsm). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate, PDB code: 3jsm:
Jump to Magnesium binding site number: 1; 2;
In total 2 binding sites of Magnesium where determined in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate, PDB code: 3jsm:
Jump to Magnesium binding site number: 1; 2;
Magnesium binding site 1 out of 2 in 3jsm
Go back to
Magnesium Binding Sites List in 3jsm
Magnesium binding site 1 out
of 2 in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
Mono view
Stereo pair view
Mono view
Stereo pair view
|
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate within 5.0Å range:
|
Magnesium binding site 2 out of 2 in 3jsm
Go back to
Magnesium Binding Sites List in 3jsm
Magnesium binding site 2 out
of 2 in the K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate
Mono view
Stereo pair view
Mono view
Stereo pair view
|
|
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of K65R Mutant Hiv-1 Reverse Transcriptase Cross-Linked to Ds-Dna and Complexed with Tenofovir-Diphosphate As the Incoming Nucleotide Substrate within 5.0Å range:
|
Reference:
K.Das,
R.P.Bandwar,
K.L.White,
J.Y.Feng,
S.G.Sarafianos,
S.Tuske,
X.Tu,
A.D.Clark,
P.L.Boyer,
X.Hou,
B.L.Gaffney,
R.A.Jones,
M.D.Miller,
S.H.Hughes,
E.Arnold.
Structural Basis For the Role of the K65R Mutation in Hiv-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance. J.Biol.Chem. V. 284 35092 2009.
ISSN: ISSN 0021-9258
PubMed: 19812032
DOI: 10.1074/JBC.M109.022525
Page generated: Wed Aug 14 17:12:00 2024
ISSN: ISSN 0021-9258
PubMed: 19812032
DOI: 10.1074/JBC.M109.022525
Last articles
Zn in 9MJ5Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF