Magnesium in PDB 4a48: Crosstalk Between Cu(I) and Zn(II) Homeostasis

All present enzymatic activity of Crosstalk Between Cu(I) and Zn(II) Homeostasis:
3.6.3.54;

The structure of Crosstalk Between Cu(I) and Zn(II) Homeostasis, PDB code: 4a48 was solved by A.Badarau, A.Basle, S.J.Firbank, C.Denninson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.52 / 1.40
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	24.660, 52.600, 39.920, 90.00, 98.13, 90.00
R / Rfree (%)	13.976 / 19.527

The structure of Crosstalk Between Cu(I) and Zn(II) Homeostasis also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Magnesium atom in the Crosstalk Between Cu(I) and Zn(II) Homeostasis (pdb code 4a48). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crosstalk Between Cu(I) and Zn(II) Homeostasis, PDB code: 4a48:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crosstalk Between Cu(I) and Zn(II) Homeostasis


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crosstalk Between Cu(I) and Zn(II) Homeostasis within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1071 b:32.2 occ:1.00 O A:HOH2013 2.1 23.6 1.0 OE2 A:GLU10 2.2 29.2 1.0 O A:HOH2022 2.4 26.1 1.0 OE1 A:GLN8 2.5 24.2 1.0 CD A:GLU10 2.9 21.2 1.0 CD A:GLN8 3.3 16.0 1.0 OE1 A:GLU10 3.4 20.6 1.0 O A:HOH2021 3.5 30.6 1.0 CG A:GLU10 3.9 17.5 1.0 NE2 A:GLN8 3.9 17.6 1.0 O A:HOH2012 4.2 21.6 1.0 NE A:ARG68 4.2 15.8 1.0 CG A:GLN8 4.3 12.6 1.0 O A:HOH2014 4.5 17.9 1.0 NH2 A:ARG68 4.6 17.7 1.0 CZ A:ARG68 4.9 16.4 1.0

Magnesium binding site 2 out of 2 in the Crosstalk Between Cu(I) and Zn(II) Homeostasis


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crosstalk Between Cu(I) and Zn(II) Homeostasis within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1071 b:22.3 occ:1.00 NH2 B:ARG62 2.4 15.2 1.0 O B:HOH2057 2.5 24.2 1.0 CZ B:ARG62 3.3 23.6 1.0 OD2 B:ASP58 3.7 22.1 1.0 NH1 B:ARG62 3.9 28.9 1.0 NE B:ARG62 4.2 26.3 1.0 O B:HOH2054 4.6 20.2 1.0 CG B:ASP58 4.9 14.4 1.0

A.Badarau, A.Basle, S.J.Firbank, C.Dennison. Investigating the Role of Zinc and Copper Binding Motifs of Trafficking Sites in the Cyanobacterium Synechocystis Pcc 6803. Biochemistry V. 52 6816 2013.
ISSN: ISSN 0006-2960
PubMed: 24050657
DOI: 10.1021/BI400492T