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Atomistry » Magnesium » PDB 4an2-4ava » 4an3 » |
Magnesium in PDB 4an3: Crystal Structures of Human MEK1 with Carboxamide-Based Allosteric Inhibitor XL518 (Gdc-0973), or Related Analogs.Enzymatic activity of Crystal Structures of Human MEK1 with Carboxamide-Based Allosteric Inhibitor XL518 (Gdc-0973), or Related Analogs.
All present enzymatic activity of Crystal Structures of Human MEK1 with Carboxamide-Based Allosteric Inhibitor XL518 (Gdc-0973), or Related Analogs.:
2.7.12.2; Protein crystallography data
The structure of Crystal Structures of Human MEK1 with Carboxamide-Based Allosteric Inhibitor XL518 (Gdc-0973), or Related Analogs., PDB code: 4an3
was solved by
K.D.Rice,
N.Aay,
N.K.Anand,
C.M.Blazey,
O.J.Bowles,
J.Bussenius,
S.Costanzo,
J.K.Curtis,
S.C.Defina,
L.Dubenko,
S.Engst,
A.A.Joshi,
A.R.Kennedy,
A.I.Kim,
E.S.Koltun,
J.C.Lougheed,
J.C.L.Manalo,
J.F.Martini,
J.M.Nuss,
C.J.Peto,
T.H.Tsang,
P.Yu,
S.Johnston,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4an3:
The structure of Crystal Structures of Human MEK1 with Carboxamide-Based Allosteric Inhibitor XL518 (Gdc-0973), or Related Analogs. also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structures of Human MEK1 with Carboxamide-Based Allosteric Inhibitor XL518 (Gdc-0973), or Related Analogs.
(pdb code 4an3). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structures of Human MEK1 with Carboxamide-Based Allosteric Inhibitor XL518 (Gdc-0973), or Related Analogs., PDB code: 4an3: Magnesium binding site 1 out of 1 in 4an3Go back to![]() ![]()
Magnesium binding site 1 out
of 1 in the Crystal Structures of Human MEK1 with Carboxamide-Based Allosteric Inhibitor XL518 (Gdc-0973), or Related Analogs.
![]() Mono view ![]() Stereo pair view
Reference:
K.D.Rice,
N.Aay,
N.K.Anand,
C.M.Blazey,
O.J.Bowles,
J.Bussenius,
S.Costanzo,
J.K.Curtis,
S.C.Defina,
L.Dubenko,
S.Engst,
A.A.Joshi,
A.R.Kennedy,
A.I.Kim,
E.S.Koltun,
J.C.Lougheed,
J.C.L.Manalo,
J.F.Martini,
J.M.Nuss,
C.J.Peto,
T.H.Tsang,
P.Yu,
S.Johnston.
Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward XL518 (Gdc-0973) Acs Med.Chem.Lett. V. 3 416 2012.
Page generated: Thu Aug 15 14:38:20 2024
ISSN: ISSN 1948-5875 PubMed: 24900486 DOI: 10.1021/ML300049D |
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