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Magnesium in PDB 4do9: Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer
Enzymatic activity of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer
All present enzymatic activity of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer, PDB code: 4do9
was solved by
V.K.Batra,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.28 / 2.05 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 50.693, 79.914, 55.607, 90.00, 107.66, 90.00 |
| R / Rfree (%) | 18.8 / 24.3 |
Other elements in 4do9:
The structure of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Chlorine | (Cl) | 5 atoms |
| Sodium | (Na) | 3 atoms |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer
(pdb code 4do9). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer, PDB code: 4do9:
In total only one binding site of Magnesium was determined in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer, PDB code: 4do9:
Magnesium binding site 1 out of 1 in 4do9
Go back to
Magnesium Binding Sites List in 4do9
Magnesium binding site 1 out
of 1 in the Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Ternary Complex of Dna Polymerase Beta with A Dideoxy Terminated Primer and 2'-Deoxyguanosine 5'-Beta, Gamma-Monofluoromethylene Triphosphate: Stereoselective Binding of R-Isomer within 5.0Å range:
|
Reference:
Y.Wu,
V.M.Zakharova,
B.A.Kashemirov,
M.F.Goodman,
V.K.Batra,
S.H.Wilson,
C.E.Mckenna.
Beta,Gamma-Chf- and Beta,Gamma-Chcl-Dgtp Diastereomers: Synthesis, Discrete (31)P uc(Nmr) Signatures, and Absolute Configurations of New Stereochemical Probes For Dna Polymerases J.Am.Chem.Soc. V. 134 8734 2012.
ISSN: ISSN 0002-7863
PubMed: 22397499
DOI: 10.1021/JA300218X
Page generated: Thu Aug 15 17:16:37 2024
ISSN: ISSN 0002-7863
PubMed: 22397499
DOI: 10.1021/JA300218X
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