Atomistry » Magnesium » PDB 4jtz-4k6e » 4k33
Atomistry »
  Magnesium »
    PDB 4jtz-4k6e »
      4k33 »

Magnesium in PDB 4k33: Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma

Enzymatic activity of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma

All present enzymatic activity of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma:
2.7.10.1;

Protein crystallography data

The structure of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma, PDB code: 4k33 was solved by Z.Huang, H.Chen, M.Mohammadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.74 / 2.34
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 54.226, 61.427, 100.666, 90.00, 90.00, 90.00
R / Rfree (%) 17.5 / 22.8

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma (pdb code 4k33). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma, PDB code: 4k33:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 4k33

Go back to Magnesium Binding Sites List in 4k33
Magnesium binding site 1 out of 2 in the Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg802

b:37.0
occ:1.00
 O2B A:ACP801 2.0 23.7 1.0
OD2 A:ASP635 2.0 31.3 1.0
OD1 A:ASN622 2.0 26.6 1.0
O A:HOH944 2.1 23.2 1.0
O2A A:ACP801 2.1 25.8 1.0
O A:HOH943 2.2 26.1 1.0
CG A:ASN622 2.9 26.8 1.0
CG A:ASP635 3.0 32.7 1.0
ND2 A:ASN622 3.3 26.2 1.0
PB A:ACP801 3.3 33.2 1.0
PA A:ACP801 3.5 30.5 1.0
CB A:ASP635 3.5 24.6 1.0
O A:HOH941 3.7 30.0 1.0
O1B A:ACP801 3.9 30.1 1.0
O3A A:ACP801 3.9 32.0 1.0
O A:HOH942 4.0 34.1 1.0
OD1 A:ASP635 4.1 32.5 1.0
O A:HOH950 4.2 47.9 1.0
O A:ARG621 4.3 30.6 1.0
CB A:ASN622 4.3 25.9 1.0
O A:HOH914 4.4 51.3 1.0
O1A A:ACP801 4.5 29.3 1.0
O5' A:ACP801 4.5 37.1 1.0
CG A:ARG621 4.5 33.2 1.0
C5' A:ACP801 4.7 32.8 1.0
CA A:ASN622 4.7 27.3 1.0
CD A:ARG621 4.8 33.5 1.0
C3B A:ACP801 4.8 34.4 1.0
C A:ARG621 4.8 26.9 1.0
NE A:ARG621 4.9 30.5 1.0
CA A:ASP635 4.9 30.6 1.0
OD2 A:ASP617 5.0 34.5 1.0

Magnesium binding site 2 out of 2 in 4k33

Go back to Magnesium Binding Sites List in 4k33
Magnesium binding site 2 out of 2 in the Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Strucure of Fgf Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, A Gain-of-Function Mutation Responsible For Thanatophoric Dysplasia Type II and Spermatocytic Seminoma within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg803

b:34.6
occ:1.00
 O A:HOH963 1.8 47.4 1.0
O1B A:ACP801 1.9 30.1 1.0
O2G A:ACP801 2.0 26.3 1.0
O A:HOH940 2.0 40.1 1.0
O A:HOH941 2.0 30.0 1.0
O A:HOH939 2.1 27.8 1.0
PB A:ACP801 3.2 33.2 1.0
O A:HOH938 3.3 75.5 1.0
PG A:ACP801 3.3 39.3 1.0
NH2 A:ARG655 3.5 50.0 1.0
C3B A:ACP801 3.8 34.4 1.0
O2B A:ACP801 3.8 23.7 1.0
OD1 A:ASP635 3.9 32.5 1.0
NZ A:LYS508 3.9 31.1 1.0
OD2 A:ASP635 4.0 31.3 1.0
O1G A:ACP801 4.1 39.2 1.0
O A:HOH920 4.3 33.4 1.0
CG A:ASP635 4.3 32.7 1.0
O3A A:ACP801 4.4 32.0 1.0
O3G A:ACP801 4.5 50.2 1.0
CZ A:ARG655 4.6 50.8 1.0
CE A:LYS508 4.6 31.5 1.0
OE1 A:GLU525 4.6 33.4 1.0
O A:HOH916 4.7 36.9 1.0

Reference:

Z.Huang, H.Chen, S.Blais, T.A.Neubert, X.Li, M.Mohammadi. Structural Mimicry of A-Loop Tyrosine Phosphorylation By A Pathogenic Fgf Receptor 3 Mutation. Structure V. 21 1889 2013.
ISSN: ISSN 0969-2126
PubMed: 23972473
DOI: 10.1016/J.STR.2013.07.017
Page generated: Sat Aug 17 03:24:40 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy