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Magnesium in PDB 4pvx: Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
Enzymatic activity of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
All present enzymatic activity of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid):
2.5.1.1; 2.5.1.10;
2.5.1.1; 2.5.1.10;
Protein crystallography data
The structure of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid), PDB code: 4pvx
was solved by
D.Rodionov,
J.Park,
Y.-S.Lin,
Y.S.Tsantrizos,
A.M.Berghuis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 69.34 / 2.18 |
| Space group | P 41 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 111.260, 111.260, 69.340, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17 / 22 |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
(pdb code 4pvx). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid), PDB code: 4pvx:
Jump to Magnesium binding site number: 1; 2; 3;
In total 3 binding sites of Magnesium where determined in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid), PDB code: 4pvx:
Jump to Magnesium binding site number: 1; 2; 3;
Magnesium binding site 1 out of 3 in 4pvx
Go back to
Magnesium Binding Sites List in 4pvx
Magnesium binding site 1 out
of 3 in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid) within 5.0Å range:
|
Magnesium binding site 2 out of 3 in 4pvx
Go back to
Magnesium Binding Sites List in 4pvx
Magnesium binding site 2 out
of 3 in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 2 of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid) within 5.0Å range:
|
Magnesium binding site 3 out of 3 in 4pvx
Go back to
Magnesium Binding Sites List in 4pvx
Magnesium binding site 3 out
of 3 in the Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 3 of Crystal Structure of Human Fpps in Complex with [({4-[4- (Cyclopropyloxy)Phenyl]Pyridin-2-Yl}Amino)Methanediyl]Bis(Phosphonic Acid) within 5.0Å range:
|
Reference:
J.Park,
D.Rodionov,
J.W.De Schutter,
Y.-S.Lin,
Y.S.Tsantrizos,
A.M.Berghuis.
Binding of Novel Phenylaminopyridine Bisphosphonate Inhibitors of Human Farnesyl Pyrophosphate Synthase to the Target Enzyme Involves Unexpected Conformational Flexibility To Be Published.
Page generated: Tue Aug 20 01:41:17 2024
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