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Atomistry » Magnesium » PDB 4rrk-4s1l » 4rwk | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 4rrk-4s1l » 4rwk » |
Magnesium in PDB 4rwk: Crystal Structure of V561M FGFR1 Gatekeeper Mutation (C488A, C584S, V561M) in Complex with N-{3-[2-(3,5-Dimethoxyphenyl)Ethyl]-1H- Pyrazol-5-Yl}-4-[(3R,5S)-3,5-Dimethylpiperazin-1-Yl]Benzamide (AZD4547)Enzymatic activity of Crystal Structure of V561M FGFR1 Gatekeeper Mutation (C488A, C584S, V561M) in Complex with N-{3-[2-(3,5-Dimethoxyphenyl)Ethyl]-1H- Pyrazol-5-Yl}-4-[(3R,5S)-3,5-Dimethylpiperazin-1-Yl]Benzamide (AZD4547)
All present enzymatic activity of Crystal Structure of V561M FGFR1 Gatekeeper Mutation (C488A, C584S, V561M) in Complex with N-{3-[2-(3,5-Dimethoxyphenyl)Ethyl]-1H- Pyrazol-5-Yl}-4-[(3R,5S)-3,5-Dimethylpiperazin-1-Yl]Benzamide (AZD4547):
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of V561M FGFR1 Gatekeeper Mutation (C488A, C584S, V561M) in Complex with N-{3-[2-(3,5-Dimethoxyphenyl)Ethyl]-1H- Pyrazol-5-Yl}-4-[(3R,5S)-3,5-Dimethylpiperazin-1-Yl]Benzamide (AZD4547), PDB code: 4rwk
was solved by
C.D.Sohl,
K.S.Anderson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of V561M FGFR1 Gatekeeper Mutation (C488A, C584S, V561M) in Complex with N-{3-[2-(3,5-Dimethoxyphenyl)Ethyl]-1H- Pyrazol-5-Yl}-4-[(3R,5S)-3,5-Dimethylpiperazin-1-Yl]Benzamide (AZD4547)
(pdb code 4rwk). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of V561M FGFR1 Gatekeeper Mutation (C488A, C584S, V561M) in Complex with N-{3-[2-(3,5-Dimethoxyphenyl)Ethyl]-1H- Pyrazol-5-Yl}-4-[(3R,5S)-3,5-Dimethylpiperazin-1-Yl]Benzamide (AZD4547), PDB code: 4rwk: Magnesium binding site 1 out of 1 in 4rwkGo back to![]() ![]()
Magnesium binding site 1 out
of 1 in the Crystal Structure of V561M FGFR1 Gatekeeper Mutation (C488A, C584S, V561M) in Complex with N-{3-[2-(3,5-Dimethoxyphenyl)Ethyl]-1H- Pyrazol-5-Yl}-4-[(3R,5S)-3,5-Dimethylpiperazin-1-Yl]Benzamide (AZD4547)
![]() Mono view ![]() Stereo pair view
Reference:
C.D.Sohl,
M.R.Ryan,
B.Luo,
K.M.Frey,
K.S.Anderson.
Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance For the FGFR1 Gatekeeper Mutation: the Achilles' Heel of Targeted Therapy. Acs Chem.Biol. V. 10 1319 2015.
Page generated: Tue Aug 20 03:32:15 2024
ISSN: ISSN 1554-8929 PubMed: 25686244 DOI: 10.1021/ACSCHEMBIO.5B00014 |
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