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Atomistry » Magnesium » PDB 4tyw-4u9h » 4u81 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 4tyw-4u9h » 4u81 » |
Magnesium in PDB 4u81: MEK1 Kinase Bound to Small Molecule Inhibitor G659Enzymatic activity of MEK1 Kinase Bound to Small Molecule Inhibitor G659
All present enzymatic activity of MEK1 Kinase Bound to Small Molecule Inhibitor G659:
2.7.12.2; Protein crystallography data
The structure of MEK1 Kinase Bound to Small Molecule Inhibitor G659, PDB code: 4u81
was solved by
K.D.Robarge,
M.H.Ultsch,
C.Weismann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4u81:
The structure of MEK1 Kinase Bound to Small Molecule Inhibitor G659 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the MEK1 Kinase Bound to Small Molecule Inhibitor G659
(pdb code 4u81). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the MEK1 Kinase Bound to Small Molecule Inhibitor G659, PDB code: 4u81: Magnesium binding site 1 out of 1 in 4u81Go back to![]() ![]()
Magnesium binding site 1 out
of 1 in the MEK1 Kinase Bound to Small Molecule Inhibitor G659
![]() Mono view ![]() Stereo pair view
Reference:
K.D.Robarge,
W.Lee,
C.Eigenbrot,
M.Ultsch,
C.Wiesmann,
R.Heald,
S.Price,
J.Hewitt,
P.Jackson,
P.Savy,
B.Burton,
E.F.Choo,
J.Pang,
J.Boggs,
A.Yang,
X.Yang,
M.Baumgardner.
Structure Based Design of Novel 6,5 Heterobicyclic Mitogen-Activated Protein Kinase Kinase (Mek) Inhibitors Leading to the Discovery of Imidazo[1,5-A] Pyrazine G-479. Bioorg.Med.Chem.Lett. V. 24 4714 2014.
Page generated: Tue Aug 20 04:28:08 2024
ISSN: ESSN 1464-3405 PubMed: 25193232 DOI: 10.1016/J.BMCL.2014.08.008 |
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