Atomistry » Magnesium » PDB 5e7c-5egc » 5eg3
Atomistry »
  Magnesium »
    PDB 5e7c-5egc »
      5eg3 »

Magnesium in PDB 5eg3: Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma)

Enzymatic activity of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma)

All present enzymatic activity of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma):
2.7.10.1; 3.1.4.11;

Protein crystallography data

The structure of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma), PDB code: 5eg3 was solved by Z.Huang, X.Li, M.Mohammadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.86 / 2.61
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 79.609, 53.231, 127.660, 90.00, 100.11, 90.00
R / Rfree (%) 18.5 / 23.7

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma) (pdb code 5eg3). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma), PDB code: 5eg3:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 5eg3

Go back to Magnesium Binding Sites List in 5eg3
Magnesium binding site 1 out of 2 in the Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg802

b:37.7
occ:1.00
MG A:MG803 2.1 28.4 1.0
OD1 A:ASN631 2.5 22.7 1.0
O1A A:ACP801 2.6 23.8 1.0
O A:ARG630 2.9 23.1 1.0
O1B A:ACP801 3.2 21.8 1.0
C5' A:ACP801 3.5 30.1 1.0
C A:ARG630 3.6 22.3 1.0
CG A:ASN631 3.7 22.7 1.0
CG A:ARG630 3.7 21.6 1.0
PA A:ACP801 3.9 25.3 1.0
CB A:ARG630 3.9 22.4 1.0
O5' A:ACP801 4.0 30.3 1.0
OD2 A:ASP644 4.0 29.3 1.0
CD A:ARG630 4.1 21.1 1.0
O3' A:ACP801 4.1 29.1 1.0
C4' A:ACP801 4.2 29.3 1.0
N A:ASN631 4.3 21.8 1.0
CA A:ARG630 4.3 23.0 1.0
CA A:ASN631 4.4 21.8 1.0
ND2 A:ASN631 4.5 23.2 1.0
PB A:ACP801 4.5 50.5 1.0
C3' A:ACP801 4.5 28.1 1.0
O3A A:ACP801 4.6 25.0 1.0
CB A:ASN631 4.7 22.0 1.0
O2B A:ACP801 4.7 51.1 1.0
NE A:ARG630 4.8 21.0 1.0
CG A:ASP644 4.9 29.6 1.0

Magnesium binding site 2 out of 2 in 5eg3

Go back to Magnesium Binding Sites List in 5eg3
Magnesium binding site 2 out of 2 in the Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of the Activated Fgf Receptor 2 (FGFR2) Kinase Domain in Complex with the CSH2 Domain of Phospholipase C Gamma (Plcgamma) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg803

b:28.4
occ:1.00
OD2 A:ASP644 2.1 29.3 1.0
MG A:MG802 2.1 37.7 1.0
O1B A:ACP801 2.2 21.8 1.0
OD1 A:ASN631 2.3 22.7 1.0
O1A A:ACP801 2.6 23.8 1.0
CG A:ASN631 3.3 22.7 1.0
CG A:ASP644 3.3 29.6 1.0
ND2 A:ASN631 3.5 23.2 1.0
PB A:ACP801 3.7 50.5 1.0
PA A:ACP801 3.7 25.3 1.0
O3A A:ACP801 3.8 25.0 1.0
O1G A:ACP801 3.9 65.5 1.0
CB A:ASP644 3.9 29.6 1.0
OD1 A:ASP644 4.3 30.0 1.0
CD A:ARG630 4.5 21.1 1.0
O2B A:ACP801 4.5 51.1 1.0
CG A:ARG630 4.5 21.6 1.0
O5' A:ACP801 4.6 30.3 1.0
O A:ARG630 4.6 23.1 1.0
NE A:ARG630 4.6 21.0 1.0
CB A:ASN631 4.6 22.0 1.0
C5' A:ACP801 4.7 30.1 1.0
OD2 A:ASP626 4.7 24.0 1.0
PG A:ACP801 4.8 74.3 1.0
O3G A:ACP801 4.8 74.3 1.0
O2A A:ACP801 4.8 24.2 1.0
C3B A:ACP801 4.9 23.6 1.0

Reference:

Z.Huang, W.M.Marsiglia, U.Basu Roy, N.Rahimi, D.Ilghari, H.Wang, H.Chen, W.Gai, S.Blais, T.A.Neubert, A.Mansukhani, N.J.Traaseth, X.Li, M.Mohammadi. Two Fgf Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C Gamma. Mol.Cell V. 61 98 2016.
ISSN: ISSN 1097-2765
PubMed: 26687682
DOI: 10.1016/J.MOLCEL.2015.11.010
Page generated: Sun Sep 29 03:41:38 2024

Last articles

Cl in 3UMG
Cl in 3UMY
Cl in 3UMR
Cl in 3UMS
Cl in 3UMC
Cl in 3UMJ
Cl in 3UMB
Cl in 3UKL
Cl in 3UM8
Cl in 3UKF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy