Atomistry » Magnesium » PDB 5fv7-5gg8 » 5g1x
Atomistry »
  Magnesium »
    PDB 5fv7-5gg8 »
      5g1x »

Magnesium in PDB 5g1x: Crystal Structure of Aurora-A Kinase in Complex with N-Myc

Enzymatic activity of Crystal Structure of Aurora-A Kinase in Complex with N-Myc

All present enzymatic activity of Crystal Structure of Aurora-A Kinase in Complex with N-Myc:
2.7.11.1;

Protein crystallography data

The structure of Crystal Structure of Aurora-A Kinase in Complex with N-Myc, PDB code: 5g1x was solved by M.W.Richards, S.G.Burgess, R.Bayliss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 74.929 / 1.72
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 86.520, 86.520, 92.210, 90.00, 90.00, 120.00
R / Rfree (%) 17.62 / 19.51

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Aurora-A Kinase in Complex with N-Myc (pdb code 5g1x). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Aurora-A Kinase in Complex with N-Myc, PDB code: 5g1x:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 5g1x

Go back to Magnesium Binding Sites List in 5g1x
Magnesium binding site 1 out of 2 in the Crystal Structure of Aurora-A Kinase in Complex with N-Myc


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Aurora-A Kinase in Complex with N-Myc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1391

b:17.4
occ:1.00
O2B A:ADP1390 2.0 18.6 1.0
OD1 A:ASP274 2.1 18.8 1.0
O A:HOH2116 2.1 19.5 1.0
O A:HOH2117 2.2 18.6 1.0
O A:HOH2185 2.2 24.6 1.0
O A:HOH2026 2.3 19.7 1.0
CG A:ASP274 2.8 17.4 1.0
OD2 A:ASP274 2.8 18.7 1.0
O A:HOH2036 3.1 30.2 1.0
O A:HOH2187 3.1 29.4 1.0
O A:HOH2186 3.1 28.5 1.0
PB A:ADP1390 3.3 17.4 1.0
O3B A:ADP1390 3.6 17.6 1.0
O A:HOH2105 3.8 19.5 1.0
NZ A:LYS162 4.0 18.4 1.0
O A:HOH2074 4.0 23.5 1.0
MG A:MG1392 4.1 16.6 1.0
O1B A:ADP1390 4.2 17.6 1.0
O A:HOH2114 4.2 19.4 1.0
CB A:ASP274 4.2 18.5 1.0
O3A A:ADP1390 4.4 17.6 1.0
OE1 A:GLU181 4.4 25.0 1.0
CA A:GLY276 4.4 18.0 1.0
N A:GLY276 4.5 18.9 1.0
O2A A:ADP1390 4.8 16.9 1.0
CA A:ASP274 4.8 18.3 1.0
PA A:ADP1390 5.0 17.9 1.0
C A:ASP274 5.0 16.2 1.0

Magnesium binding site 2 out of 2 in 5g1x

Go back to Magnesium Binding Sites List in 5g1x
Magnesium binding site 2 out of 2 in the Crystal Structure of Aurora-A Kinase in Complex with N-Myc


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Aurora-A Kinase in Complex with N-Myc within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1392

b:16.6
occ:1.00
OD2 A:ASP274 1.8 18.7 1.0
O2A A:ADP1390 2.0 16.9 1.0
O3B A:ADP1390 2.0 17.6 1.0
O A:HOH2114 2.1 19.4 1.0
OD1 A:ASN261 2.1 18.1 1.0
O A:HOH2112 2.2 19.0 1.0
CG A:ASP274 2.9 17.4 1.0
CG A:ASN261 3.1 19.2 1.0
PB A:ADP1390 3.2 17.4 1.0
PA A:ADP1390 3.3 17.9 1.0
ND2 A:ASN261 3.5 17.0 1.0
O3A A:ADP1390 3.6 17.6 1.0
CB A:ASP274 3.6 18.5 1.0
O2B A:ADP1390 3.7 18.6 1.0
O A:HOH2117 3.8 18.6 1.0
OD1 A:ASP274 3.9 18.8 1.0
O A:HOH2184 4.0 27.3 1.0
MG A:MG1391 4.1 17.4 1.0
O A:HOH2109 4.2 29.8 1.0
O5' A:ADP1390 4.3 19.2 1.0
O1A A:ADP1390 4.3 18.8 1.0
O A:HOH2111 4.3 20.3 1.0
CB A:ASN261 4.5 18.1 1.0
C5' A:ADP1390 4.5 17.8 1.0
O1B A:ADP1390 4.5 17.6 1.0
O A:GLU260 4.6 22.6 1.0
O A:HOH2015 4.6 41.2 1.0
O3' A:ADP1390 4.7 20.4 1.0
CG A:GLU260 4.8 27.7 1.0
CA A:ASN261 4.9 17.5 1.0
OE2 A:GLU260 4.9 43.3 1.0

Reference:

M.Richards, S.Burgess, E.Poon, A.Carstensen, M.Eilers, L.Chesler, R.Bayliss. Structural Basis of N-Myc Binding By Aurora-A and Its Destabilization By Kinase Inhibitors Proc.Natl.Acad.Sci.Usa V. 113 13726 2016.
ISSN: ISSN 0027-8424
PubMed: 27837025
DOI: 10.1073/PNAS.1610626113
Page generated: Sun Sep 29 04:34:38 2024

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy