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Magnesium in PDB 5g22: Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26)

Enzymatic activity of Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26)

All present enzymatic activity of Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26):
2.3.1.97;

Protein crystallography data

The structure of Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26), PDB code: 5g22 was solved by V.Goncalves, J.A.Brannigan, A.Laporte, A.S.Bell, S.M.Roberts, A.J.Wilkinson, R.J.Leatherbarrow, E.W.Tate, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 101.64 / 2.32
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 57.970, 123.360, 179.370, 90.00, 90.00, 90.00
R / Rfree (%) 22 / 28.3

Other elements in 5g22:

The structure of Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26) also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26) (pdb code 5g22). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26), PDB code: 5g22:
Jump to Magnesium binding site number: 1; 2; 3;

Magnesium binding site 1 out of 3 in 5g22

Go back to Magnesium Binding Sites List in 5g22
Magnesium binding site 1 out of 3 in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1412

b:36.7
occ:1.00
O A:LEU169 2.9 15.1 1.0
O2A A:NHW1000 3.0 14.8 1.0
N A:LYS172 3.0 24.4 1.0
O4A A:NHW1000 3.2 15.5 1.0
N A:LEU174 3.2 19.8 1.0
CB A:LEU174 3.4 20.1 1.0
N A:ARG173 3.4 22.3 1.0
CA A:LYS172 3.5 25.5 1.0
CB A:LYS172 3.5 25.1 1.0
C A:LYS172 3.5 24.1 1.0
N A:SER171 3.8 19.6 1.0
CA A:LEU174 3.9 19.3 1.0
P1A A:NHW1000 3.9 15.2 1.0
CD1 A:LEU174 3.9 21.9 1.0
C A:ARG170 3.9 18.8 1.0
O1A A:NHW1000 4.0 15.4 1.0
C A:LEU169 4.0 16.8 1.0
CA A:ARG170 4.1 17.5 1.0
CG A:LEU174 4.1 20.7 1.0
CG1 A:VAL165 4.1 15.6 1.0
C A:SER171 4.2 23.5 1.0
C A:ARG173 4.2 21.7 1.0
O A:LYS172 4.3 25.4 1.0
CA A:ARG173 4.3 22.0 1.0
P2A A:NHW1000 4.3 16.8 1.0
CA A:SER171 4.4 21.4 1.0
N A:ALA175 4.5 18.4 1.0
O A:ARG170 4.5 18.5 1.0
N A:ARG170 4.5 17.0 1.0
O3A A:NHW1000 4.6 15.4 1.0
CG A:LYS172 4.6 27.5 1.0
O6A A:NHW1000 4.7 16.1 1.0
C A:LEU174 4.7 19.1 1.0
CG2 A:VAL165 4.8 16.2 1.0
CB A:VAL165 4.9 16.9 1.0
CD A:LYS172 5.0 27.2 1.0

Magnesium binding site 2 out of 3 in 5g22

Go back to Magnesium Binding Sites List in 5g22
Magnesium binding site 2 out of 3 in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg1411

b:33.9
occ:1.00
O2A B:NHW1000 2.7 16.9 1.0
N B:LYS172 2.9 21.0 1.0
O4A B:NHW1000 3.0 14.8 1.0
O B:LEU169 3.0 20.6 1.0
N B:LEU174 3.1 18.5 1.0
N B:ARG173 3.3 21.6 1.0
CB B:LEU174 3.5 18.2 1.0
CA B:LYS172 3.5 21.3 0.5
CA B:LYS172 3.5 21.4 0.5
C B:LYS172 3.6 21.2 1.0
P1A B:NHW1000 3.6 16.8 1.0
CB B:LYS172 3.6 21.8 0.5
CB B:LYS172 3.6 22.0 0.5
N B:SER171 3.6 19.9 1.0
CA B:LEU174 3.8 17.7 1.0
O1A B:NHW1000 3.8 18.7 1.0
C B:SER171 4.0 20.5 1.0
CG B:LEU174 4.0 18.4 1.0
C B:ARG170 4.0 20.5 1.0
C B:ARG173 4.0 20.3 1.0
P2A B:NHW1000 4.1 14.5 1.0
CA B:ARG173 4.1 21.9 1.0
CD1 B:LEU174 4.1 18.4 1.0
C B:LEU169 4.2 19.2 1.0
CA B:SER171 4.2 20.5 1.0
O3A B:NHW1000 4.2 16.0 1.0
CA B:ARG170 4.2 19.5 1.0
N B:ALA175 4.3 16.7 1.0
CG1 B:VAL165 4.3 14.8 1.0
O6A B:NHW1000 4.5 14.7 1.0
O B:LYS172 4.5 20.4 1.0
C B:LEU174 4.5 17.1 1.0
CG B:LYS172 4.5 22.8 0.5
CG B:LYS172 4.6 23.3 0.5
N B:ARG170 4.7 18.7 1.0
O B:ARG170 4.7 21.0 1.0
CG2 B:VAL165 4.8 15.4 1.0
CB B:VAL165 4.9 15.5 1.0

Magnesium binding site 3 out of 3 in 5g22

Go back to Magnesium Binding Sites List in 5g22
Magnesium binding site 3 out of 3 in the Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26)


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Plasmodium Vivax N-Myristoyltransferase in Complex with A Quinoline Inhibitor (Compound 26) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mg1411

b:29.8
occ:1.00
O2A C:NHW1000 2.7 17.7 1.0
O4A C:NHW1000 2.8 14.3 1.0
N C:LYS172 3.0 20.8 0.5
N C:LYS172 3.0 20.8 0.5
N C:LEU174 3.1 19.4 1.0
O C:LEU169 3.1 18.7 1.0
CB C:LEU174 3.3 18.0 1.0
N C:ARG173 3.3 21.7 1.0
N C:SER171 3.5 18.4 1.0
P1A C:NHW1000 3.6 17.7 1.0
CA C:LYS172 3.6 21.6 0.5
CA C:LYS172 3.7 21.6 0.5
C C:LYS172 3.7 21.3 0.5
C C:LYS172 3.7 21.3 0.5
CB C:LYS172 3.7 21.6 0.5
CA C:LEU174 3.8 17.8 1.0
P2A C:NHW1000 3.8 15.7 1.0
O1A C:NHW1000 3.8 19.0 1.0
CG C:LEU174 3.9 18.2 1.0
CB C:LYS172 3.9 21.6 0.5
C C:ARG170 3.9 18.3 1.0
C C:SER171 4.0 20.6 1.0
O3A C:NHW1000 4.1 16.7 1.0
CD1 C:LEU174 4.1 17.4 1.0
C C:ARG173 4.1 20.4 1.0
CA C:SER171 4.1 20.2 1.0
CA C:ARG170 4.1 17.5 1.0
CA C:ARG173 4.2 21.2 1.0
C C:LEU169 4.3 18.4 1.0
CG C:LYS172 4.3 21.6 0.5
N C:ALA175 4.3 17.2 1.0
O6A C:NHW1000 4.4 15.3 1.0
O C:LYS172 4.5 22.2 0.5
C C:LEU174 4.5 17.7 1.0
CG1 C:VAL165 4.5 12.7 1.0
O C:LYS172 4.6 22.1 0.5
O C:ARG170 4.7 19.7 1.0
N C:ARG170 4.7 17.8 1.0
CG2 C:VAL165 4.8 12.6 1.0
CG C:LYS172 4.8 21.4 0.5

Reference:

V.Goncalves, J.A.Brannigan, A.Laporte, A.S.Bell, S.M.Roberts, A.J.Wilkinson, R.J.Leatherbarrow, E.W.Tate. Structure-Guided Optimization of Quinoline Inhibitors of Plasmodium N-Myristoyltransferase. Medchemcomm V. 8 191 2017.
ISSN: ISSN 2040-2503
PubMed: 28626547
DOI: 10.1039/C6MD00531D
Page generated: Sun Sep 29 04:35:07 2024

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