Atomistry » Magnesium » PDB 5mh6-5mtv » 5mp8
Atomistry »
  Magnesium »
    PDB 5mh6-5mtv »
      5mp8 »

Magnesium in PDB 5mp8: Crystal Structure of CK2ALPHA with ZT0432 Bound

Enzymatic activity of Crystal Structure of CK2ALPHA with ZT0432 Bound

All present enzymatic activity of Crystal Structure of CK2ALPHA with ZT0432 Bound:
2.7.11.1;

Protein crystallography data

The structure of Crystal Structure of CK2ALPHA with ZT0432 Bound, PDB code: 5mp8 was solved by P.Brear, C.De Fusco, K.Georgiou, J.Iegre, H.Sore, M.Hyvonen, D.Spring, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.16 / 1.92
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 65.170, 68.340, 331.450, 90.00, 90.00, 90.00
R / Rfree (%) 21.2 / 22.4

Other elements in 5mp8:

The structure of Crystal Structure of CK2ALPHA with ZT0432 Bound also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of CK2ALPHA with ZT0432 Bound (pdb code 5mp8). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of CK2ALPHA with ZT0432 Bound, PDB code: 5mp8:

Magnesium binding site 1 out of 1 in 5mp8

Go back to Magnesium Binding Sites List in 5mp8
Magnesium binding site 1 out of 1 in the Crystal Structure of CK2ALPHA with ZT0432 Bound


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of CK2ALPHA with ZT0432 Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg407

b:30.0
occ:1.00
OD2 A:ASP175 2.3 35.2 1.0
OD1 A:ASN161 2.5 13.4 1.0
O1A A:ADP404 2.5 53.4 1.0
O1B A:ADP404 2.6 57.6 1.0
CG A:ASP175 3.1 26.8 1.0
CG A:ASN161 3.5 26.2 1.0
CB A:ASP175 3.5 12.3 1.0
PB A:ADP404 3.6 61.3 1.0
PA A:ADP404 3.7 52.2 1.0
ND2 A:ASN161 3.7 12.9 1.0
O3A A:ADP404 3.9 58.3 1.0
O3B A:ADP404 4.0 59.8 1.0
OD1 A:ASP175 4.1 28.1 1.0
CE A:LYS158 4.5 24.0 1.0
O2A A:ADP404 4.6 52.0 1.0
OD2 A:ASP156 4.6 22.9 1.0
O5' A:ADP404 4.7 50.5 1.0
C5' A:ADP404 4.7 50.5 1.0
O3' A:ADP404 4.8 50.1 1.0
NZ A:LYS158 4.8 33.0 1.0
CB A:ASN161 4.8 10.0 1.0
O2B A:ADP404 4.9 65.9 1.0

Reference:

C.De Fusco, P.Brear, J.Iegre, K.H.Georgiou, H.F.Sore, M.Hyvonen, D.R.Spring. A Fragment-Based Approach Leading to the Discovery of A Novel Binding Site and the Selective CK2 Inhibitor CAM4066. Bioorg. Med. Chem. V. 25 3471 2017.
ISSN: ESSN 1464-3391
PubMed: 28495381
DOI: 10.1016/J.BMC.2017.04.037
Page generated: Sun Sep 29 22:01:31 2024

Last articles

Cl in 3L28
Cl in 3L27
Cl in 3L29
Cl in 3L26
Cl in 3L25
Cl in 3L12
Cl in 3L21
Cl in 3L1S
Cl in 3L1R
Cl in 3L14
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy