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Magnesium in PDB 5tfg: Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp
Enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp
All present enzymatic activity of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp:
3.6.3.49;
3.6.3.49;
Protein crystallography data
The structure of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp, PDB code: 5tfg
was solved by
C.Wang,
A.A.Aleksandrov,
Z.Yang,
F.Forouhar,
E.Proctor,
P.Kota,
J.An,
A.Kaplan,
N.Khazanov,
G.Boel,
B.R.Stockwell,
H.Senderowitz,
N.V.Dokholyan,
J.R.Riordan,
C.G.Brouillette,
J.F.Hunt,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 40.15 / 1.91 |
| Space group | P 43 |
| Cell size a, b, c (Å), α, β, γ (°) | 40.147, 40.147, 141.787, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 15.6 / 18.4 |
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp
(pdb code 5tfg). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp, PDB code: 5tfg:
In total only one binding site of Magnesium was determined in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp, PDB code: 5tfg:
Magnesium binding site 1 out of 1 in 5tfg
Go back to
Magnesium Binding Sites List in 5tfg
Magnesium binding site 1 out
of 1 in the Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Magnesium with other atoms in the Mg binding
site number 1 of Nucleotide-Binding Domain 1 of the Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with 5-Methyl-Utp within 5.0Å range:
|
Reference:
C.Wang,
A.A.Aleksandrov,
Z.Yang,
F.Forouhar,
E.Proctor,
P.Kota,
J.An,
A.Kaplan,
N.Khazanov,
G.Boel,
B.R.Stockwell,
H.Senderowitz,
N.V.Dokholyan,
J.R.Riordan,
C.G.Brouillette,
J.F.Hunt.
Thermodynamic Correction of F508DEL-Cftr By Ligand Binding to A Remote Site in the Mutated Domain To Be Published.
Page generated: Tue Aug 12 20:29:19 2025
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