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Atomistry » Magnesium » PDB 5zkj-6a1l » 5zz2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 5zkj-6a1l » 5zz2 » |
Magnesium in PDB 5zz2: Crystal Structure of PDE5 in Complex with Inhibitor LW1634Enzymatic activity of Crystal Structure of PDE5 in Complex with Inhibitor LW1634
All present enzymatic activity of Crystal Structure of PDE5 in Complex with Inhibitor LW1634:
3.1.4.35; Protein crystallography data
The structure of Crystal Structure of PDE5 in Complex with Inhibitor LW1634, PDB code: 5zz2
was solved by
D.Wu,
Y.D.Huang,
Y.Y.Huang,
H.B.Luo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5zz2:
The structure of Crystal Structure of PDE5 in Complex with Inhibitor LW1634 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of PDE5 in Complex with Inhibitor LW1634
(pdb code 5zz2). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of PDE5 in Complex with Inhibitor LW1634, PDB code: 5zz2: Magnesium binding site 1 out of 1 in 5zz2Go back to![]() ![]()
Magnesium binding site 1 out
of 1 in the Crystal Structure of PDE5 in Complex with Inhibitor LW1634
![]() Mono view ![]() Stereo pair view
Reference:
D.Wu,
Y.Huang,
Y.Chen,
Y.Y.Huang,
H.Geng,
T.Zhang,
C.Zhang,
Z.Li,
L.Guo,
J.Chen,
H.B.Luo.
Optimization of Chromeno[2,3- C]Pyrrol-9(2 H)-Ones As Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-Ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. J. Med. Chem. V. 61 8468 2018.
Page generated: Mon Sep 30 18:45:35 2024
ISSN: ISSN 1520-4804 PubMed: 30148362 DOI: 10.1021/ACS.JMEDCHEM.8B01209 |
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