Magnesium in PDB 6p2g: Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dsdna and D-Ddctp

All present enzymatic activity of Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dsdna and D-Ddctp:
2.7.7.49; 2.7.7.7; 3.1.26.13;

The structure of Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dsdna and D-Ddctp, PDB code: 6p2g was solved by N.Bertoletti, K.S.Anderson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.59 / 2.99
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	168.548, 171.578, 106.001, 90.00, 90.00, 90.00
R / Rfree (%)	21.5 / 26.7

The binding sites of Magnesium atom in the Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dsdna and D-Ddctp (pdb code 6p2g). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dsdna and D-Ddctp, PDB code: 6p2g:

Magnesium binding site 1 out of 1 in the Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dsdna and D-Ddctp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Hiv-1 Reverse Transcriptase (Rt) in Complex with Dsdna and D-Ddctp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg602 b:32.6 occ:1.00 OD2 A:ASP185 2.0 48.6 1.0 OD1 A:ASP110 2.2 46.5 1.0 O A:VAL111 2.3 44.6 1.0 O3A A:DCT601 2.4 46.4 1.0 O2G A:DCT601 2.5 48.9 1.0 O2B A:DCT601 2.7 43.0 1.0 PB A:DCT601 3.2 44.1 1.0 CG A:ASP185 3.2 47.5 1.0 CG A:ASP110 3.3 47.4 1.0 C A:VAL111 3.5 43.8 1.0 PA A:DCT601 3.5 52.0 1.0 O2A A:DCT601 3.7 53.9 1.0 PG A:DCT601 3.7 47.7 1.0 OD2 A:ASP110 3.8 59.3 1.0 O3B A:DCT601 3.8 46.3 1.0 OD1 A:ASP185 3.8 42.7 1.0 O5' A:DCT601 3.8 40.1 1.0 N A:VAL111 4.1 44.4 1.0 CB A:ASP185 4.3 45.6 1.0 CA A:VAL111 4.3 43.2 1.0 CB A:ALA114 4.4 42.1 1.0 N A:GLY112 4.4 39.0 1.0 O3G A:DCT601 4.5 37.5 1.0 O1B A:DCT601 4.5 41.2 1.0 CA A:GLY112 4.5 38.7 1.0 C5' A:DCT601 4.5 42.1 1.0 CB A:ASP110 4.5 43.7 1.0 N A:ASP113 4.6 38.2 1.0 N A:ALA114 4.6 40.2 1.0 O1G A:DCT601 4.8 48.2 1.0 C A:GLY112 4.8 40.3 1.0 O1A A:DCT601 4.8 40.0 1.0 C A:ASP110 4.8 44.3 1.0 CB A:VAL111 4.9 40.3 1.0

N.Bertoletti, A.H.Chan, R.F.Schinazi, Y.W.Yin, K.S.Anderson. Structural Insights Into the Recognition of Nucleoside Reverse Transcriptase Inhibitors By Hiv-1 Reverse Transcriptase: First Crystal Structures with Reverse Transcriptase and the Active Triphosphate Forms of Lamivudine and Emtricitabine. Protein Sci. V. 28 1664 2019.
ISSN: ESSN 1469-896X
PubMed: 31301259
DOI: 10.1002/PRO.3681