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Atomistry » Magnesium » PDB 6s5d-6sh6 » 6s88 » |
Magnesium in PDB 6s88: Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(2-Methoxy-5-((1,2,4,5-Tetrahydro- 3H-Benzo[D]Azepin-3-Yl)Sulfonyl)Phenyl)-2-(4-Oxo-3,4- Dihydrophthalazin-1-Yl)AcetamideEnzymatic activity of Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(2-Methoxy-5-((1,2,4,5-Tetrahydro- 3H-Benzo[D]Azepin-3-Yl)Sulfonyl)Phenyl)-2-(4-Oxo-3,4- Dihydrophthalazin-1-Yl)Acetamide
All present enzymatic activity of Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(2-Methoxy-5-((1,2,4,5-Tetrahydro- 3H-Benzo[D]Azepin-3-Yl)Sulfonyl)Phenyl)-2-(4-Oxo-3,4- Dihydrophthalazin-1-Yl)Acetamide:
4.2.1.2; Protein crystallography data
The structure of Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(2-Methoxy-5-((1,2,4,5-Tetrahydro- 3H-Benzo[D]Azepin-3-Yl)Sulfonyl)Phenyl)-2-(4-Oxo-3,4- Dihydrophthalazin-1-Yl)Acetamide, PDB code: 6s88
was solved by
A.J.Whitehouse,
M.D.Libardo,
M.Kasbekar,
P.Brear,
G.Fischer,
C.J.Thomas,
C.E.Barry,
H.I.Boshoff,
A.G.Coyne,
C.Abell,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(2-Methoxy-5-((1,2,4,5-Tetrahydro- 3H-Benzo[D]Azepin-3-Yl)Sulfonyl)Phenyl)-2-(4-Oxo-3,4- Dihydrophthalazin-1-Yl)Acetamide
(pdb code 6s88). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(2-Methoxy-5-((1,2,4,5-Tetrahydro- 3H-Benzo[D]Azepin-3-Yl)Sulfonyl)Phenyl)-2-(4-Oxo-3,4- Dihydrophthalazin-1-Yl)Acetamide, PDB code: 6s88: Magnesium binding site 1 out of 1 in 6s88Go back to![]() ![]()
Magnesium binding site 1 out
of 1 in the Fumarate Hydratase of Mycobacterium Tuberculosis in Complex with Formate and Allosteric Modulator N-(2-Methoxy-5-((1,2,4,5-Tetrahydro- 3H-Benzo[D]Azepin-3-Yl)Sulfonyl)Phenyl)-2-(4-Oxo-3,4- Dihydrophthalazin-1-Yl)Acetamide
![]() Mono view ![]() Stereo pair view
Reference:
A.J.Whitehouse,
M.D.J.Libardo,
M.Kasbekar,
P.D.Brear,
G.Fischer,
C.J.Thomas,
C.Barry,
H.I.M.Boshoff,
A.G.Coyne,
C.Abell.
Targeting of Fumarate Hydratase From Mycobacterium Tuberculosis Using Allosteric Inhibitors with A Dimeric-Binding Mode. J.Med.Chem. 2019.
Page generated: Tue Oct 1 17:48:42 2024
ISSN: ISSN 0022-2623 PubMed: 31517489 DOI: 10.1021/ACS.JMEDCHEM.9B01203 |
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