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Magnesium in PDB 6tt2: The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C

Enzymatic activity of The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C

All present enzymatic activity of The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C:
2.7.10.2;

Protein crystallography data

The structure of The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C, PDB code: 6tt2 was solved by P.Brear, J.Wagstaff, M.Hyvonen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.83 / 1.36
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 49.247, 60.374, 56.394, 90.00, 98.12, 90.00
R / Rfree (%) 20.3 / 23.4

Other elements in 6tt2:

The structure of The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C (pdb code 6tt2). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C, PDB code: 6tt2:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 6tt2

Go back to Magnesium Binding Sites List in 6tt2
Magnesium binding site 1 out of 2 in the The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg201

b:27.2
occ:1.00
O A:HOH359 1.9 29.6 1.0
O A:HOH313 2.2 30.5 1.0
O A:HOH346 4.0 35.0 1.0
OE2 A:GLU7 4.3 36.3 1.0
O A:GLY47 4.3 29.3 1.0
OE1 A:GLU7 4.4 34.7 1.0
CD A:GLU7 4.8 39.8 1.0

Magnesium binding site 2 out of 2 in 6tt2

Go back to Magnesium Binding Sites List in 6tt2
Magnesium binding site 2 out of 2 in the The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of The pH Domain of Bruton'S Tyrosine Kinase Mutant R28C within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg201

b:25.7
occ:1.00
O B:HOH338 2.0 28.6 1.0
O B:HOH307 2.0 27.7 1.0
O B:HOH304 2.1 24.9 1.0
O B:HOH411 2.2 29.2 1.0
O B:HOH357 3.9 31.8 1.0
OE2 B:GLU7 4.1 26.7 1.0
O B:GLY47 4.2 28.6 1.0
OE1 B:GLU7 4.2 25.4 1.0
CD B:GLU7 4.6 24.7 1.0
O B:HOH356 4.8 36.2 1.0

Reference:

P.Brear, G.Fischer, M.May, T.Pantelejevs, R.Mathieu, M.Rossmann, J.Wagstaff, B.Blaszczyk, M.Hyvonen. Crystal Structure of 1-Methylindoline-2,3-Dione Covalently Bound to the pH Domain of Bruton'S Tyrosine Kinase Mutant R28C To Be Published.
Page generated: Wed Aug 13 18:11:00 2025

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