Magnesium in PDB 7bi6: PI3KC2A Core in Complex with Atp

All present enzymatic activity of PI3KC2A Core in Complex with Atp:
2.7.1.154;

The structure of PI3KC2A Core in Complex with Atp, PDB code: 7bi6 was solved by W.T.Lo, Y.Roske, O.Daumke, V.Haucke, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.56 / 2.75
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.124, 133.371, 152.709, 90, 90, 90
R / Rfree (%)	24.4 / 28.9

The binding sites of Magnesium atom in the PI3KC2A Core in Complex with Atp (pdb code 7bi6). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the PI3KC2A Core in Complex with Atp, PDB code: 7bi6:

Magnesium binding site 1 out of 1 in the PI3KC2A Core in Complex with Atp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of PI3KC2A Core in Complex with Atp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1106 b:70.6 occ:1.00 O1B A:ATP1101 2.4 103.1 1.0 OE1 A:GLU759 2.7 88.4 1.0 OD1 A:ASP886 3.0 78.5 1.0 CD A:GLU759 3.4 87.6 1.0 OE2 A:GLU759 3.4 88.8 1.0 O1A A:ATP1101 3.4 92.7 1.0 NZ A:LYS756 3.6 79.4 1.0 O1G A:ATP1101 3.8 109.2 1.0 PB A:ATP1101 3.9 102.9 1.0 CG A:ASP886 4.1 77.1 1.0 CE A:LYS756 4.2 78.9 1.0 PA A:ATP1101 4.3 93.5 1.0 O3A A:ATP1101 4.5 98.1 1.0 PG A:ATP1101 4.6 109.3 1.0 O3B A:ATP1101 4.6 105.8 1.0 O2A A:ATP1101 4.7 93.3 1.0 O2G A:ATP1101 4.7 109.1 1.0 CB A:ASP886 4.8 76.1 1.0 CD A:LYS756 4.9 78.4 1.0 CG A:GLU759 4.9 86.1 1.0 O2B A:ATP1101 4.9 102.2 1.0 OD2 A:ASP886 5.0 78.0 1.0

W.T.Lo, Y.Zhang, O.Vadas, Y.Roske, F.Gulluni, M.C.De Santis, A.V.Zagar, H.Stephanowitz, E.Hirsch, F.Liu, O.Daumke, M.Kudryashev, V.Haucke. Structural Basis of Phosphatidylinositol 3-Kinase C2 Alpha Function. Nat.Struct.Mol.Biol. V. 29 218 2022.
ISSN: ESSN 1545-9985
PubMed: 35256802
DOI: 10.1038/S41594-022-00730-W