Magnesium in PDB 7otx: Hiv-1 Reverse Transcriptase Complex with Dna and Inhibitor Rmc-257

All present enzymatic activity of Hiv-1 Reverse Transcriptase Complex with Dna and Inhibitor Rmc-257:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13;

The structure of Hiv-1 Reverse Transcriptase Complex with Dna and Inhibitor Rmc-257, PDB code: 7otx was solved by S.E.Martinez, A.K.Singh, W.Gu, K.Das, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	53.93 / 3.45
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	89.817, 132.878, 139.589, 90, 98.78, 90
R / Rfree (%)	21.3 / 25.1

The binding sites of Magnesium atom in the Hiv-1 Reverse Transcriptase Complex with Dna and Inhibitor Rmc-257 (pdb code 7otx). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Hiv-1 Reverse Transcriptase Complex with Dna and Inhibitor Rmc-257, PDB code: 7otx:

Magnesium binding site 1 out of 1 in the Hiv-1 Reverse Transcriptase Complex with Dna and Inhibitor Rmc-257


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Hiv-1 Reverse Transcriptase Complex with Dna and Inhibitor Rmc-257 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg601 b:204.0 occ:1.00 O17 A:1IK602 2.3 239.3 1.0 O18 A:1IK602 2.6 255.9 1.0 C16 A:1IK602 2.6 249.8 1.0 OD2 A:ASP185 2.8 212.8 1.0 OD1 A:ASP110 2.9 215.8 1.0 OD2 A:ASP110 3.3 214.1 1.0 CG A:ASP110 3.5 216.2 1.0 CG A:ASP185 3.6 196.9 1.0 OD1 A:ASP185 3.6 171.9 1.0 C15 A:1IK602 3.9 256.5 1.0 N14 A:1IK602 4.1 241.0 1.0 C3' P:DDG822 4.1 214.3 1.0 O A:VAL111 4.3 205.8 1.0 C2' P:DDG822 4.3 209.7 1.0 C19 A:1IK602 4.7 260.6 1.0 CB A:ASP110 5.0 205.6 1.0

W.Gu, S.E.Martinez, A.K.Singh, H.Nguyen, J.Rozenski, D.Schols, P.Herdewijn, K.Das, S.De Jonghe. Exploring the Dntp -Binding Site of Hiv-1 Reverse Transcriptase For Inhibitor Design Eur.J.Med.Chem. V. 225 2021.
ISSN: ISSN 0223-5234
DOI: 10.1016/J.EJMECH.2021.113785