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Atomistry » Magnesium » PDB 7y43-7yga » 7ycc | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 7y43-7yga » 7ycc » |
Magnesium in PDB 7ycc: Kras G12C in Complex with Compound 5CEnzymatic activity of Kras G12C in Complex with Compound 5C
All present enzymatic activity of Kras G12C in Complex with Compound 5C:
3.6.5.2; Protein crystallography data
The structure of Kras G12C in Complex with Compound 5C, PDB code: 7ycc
was solved by
Y.Amano,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7ycc:
The structure of Kras G12C in Complex with Compound 5C also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Kras G12C in Complex with Compound 5C
(pdb code 7ycc). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 3 binding sites of Magnesium where determined in the Kras G12C in Complex with Compound 5C, PDB code: 7ycc: Jump to Magnesium binding site number: 1; 2; 3; Magnesium binding site 1 out of 3 in 7yccGo back to![]() ![]()
Magnesium binding site 1 out
of 3 in the Kras G12C in Complex with Compound 5C
![]() Mono view ![]() Stereo pair view
Magnesium binding site 2 out of 3 in 7yccGo back to![]() ![]()
Magnesium binding site 2 out
of 3 in the Kras G12C in Complex with Compound 5C
![]() Mono view ![]() Stereo pair view
Magnesium binding site 3 out of 3 in 7yccGo back to![]() ![]()
Magnesium binding site 3 out
of 3 in the Kras G12C in Complex with Compound 5C
![]() Mono view ![]() Stereo pair view
Reference:
T.Imaizumi,
M.Akaiwa,
T.Abe,
T.Nigawara,
T.Koike,
Y.Satake,
K.Watanabe,
O.Kaneko,
Y.Amano,
K.Mori,
Y.Yamanaka,
T.Nagashima,
M.Shimazaki,
K.Kuramoto.
Discovery and Biological Evaluation of 1-{2,7-Diazaspiro[3.5]Nonan-2-Yl}Prop-2-En-1-One Derivatives As Covalent Inhibitors of Kras G12C with Favorable Metabolic Stability and Anti-Tumor Activity. Bioorg.Med.Chem. V. 71 16949 2022.
Page generated: Thu Oct 3 14:38:12 2024
ISSN: ESSN 1464-3391 PubMed: 35926326 DOI: 10.1016/J.BMC.2022.116949 |
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