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Atomistry » Magnesium » PDB 7y43-7yga » 7yce | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 7y43-7yga » 7yce » |
Magnesium in PDB 7yce: Kras G12C in Complex with Compound 7BEnzymatic activity of Kras G12C in Complex with Compound 7B
All present enzymatic activity of Kras G12C in Complex with Compound 7B:
3.6.5.2; Protein crystallography data
The structure of Kras G12C in Complex with Compound 7B, PDB code: 7yce
was solved by
Y.Amano,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7yce:
The structure of Kras G12C in Complex with Compound 7B also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Kras G12C in Complex with Compound 7B
(pdb code 7yce). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Kras G12C in Complex with Compound 7B, PDB code: 7yce: Magnesium binding site 1 out of 1 in 7yceGo back to![]() ![]()
Magnesium binding site 1 out
of 1 in the Kras G12C in Complex with Compound 7B
![]() Mono view ![]() Stereo pair view
Reference:
T.Imaizumi,
M.Akaiwa,
T.Abe,
T.Nigawara,
T.Koike,
Y.Satake,
K.Watanabe,
O.Kaneko,
Y.Amano,
K.Mori,
Y.Yamanaka,
T.Nagashima,
M.Shimazaki,
K.Kuramoto.
Discovery and Biological Evaluation of 1-{2,7-Diazaspiro[3.5]Nonan-2-Yl}Prop-2-En-1-One Derivatives As Covalent Inhibitors of Kras G12C with Favorable Metabolic Stability and Anti-Tumor Activity. Bioorg.Med.Chem. V. 71 16949 2022.
Page generated: Thu Oct 3 14:38:29 2024
ISSN: ESSN 1464-3391 PubMed: 35926326 DOI: 10.1016/J.BMC.2022.116949 |
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