Magnesium in PDB 8axz: Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.

Enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.

All present enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.:
2.5.1.6;

Protein crystallography data

The structure of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid., PDB code: 8axz was solved by A.Nawrotek, L.Vuillard, L.Miallau, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	58.63 / 1.15
*Space group*	I 2 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	67.554, 94.387, 117.266, 90, 90, 90
*R / R_free (%)*	16.8 / 18.5

Other elements in 8axz:

Potassium

(K)

2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid. (pdb code 8axz). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid., PDB code: 8axz:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 8axz

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Magnesium Binding Sites List in 8axz

Magnesium binding site 1 out of 2 in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mg402 b:7.0 occ:0.70	O3G	A:PPK401	2.0	6.2	0.5
	O4A	A:PPK401	2.0	4.7	0.5
	OD2	A:ASP31	2.1	9.9	1.0
	O	A:HOH555	2.1	12.8	1.0
	O2B	A:PPK401	2.1	13.2	0.5
	O	A:HOH514	2.2	13.9	1.0
	CG	A:ASP31	3.0	8.2	1.0
	PB	A:PPK401	3.1	17.4	0.5
	OD1	A:ASP31	3.3	8.9	1.0
	PG	A:PPK401	3.3	8.8	0.5
	PA	A:PPK401	3.3	4.9	0.5
	N3B	A:PPK401	3.5	11.8	0.5
	NZ	A:LYS265	3.5	9.6	1.0
	O3A	A:PPK401	3.7	7.7	0.5
	K	A:K404	3.8	14.4	0.7
	NH2	A:ARG264	4.1	12.5	1.0
	OD2	A:ASP258	4.2	15.5	0.8
	O2A	A:PPK401	4.2	7.1	0.5
	O1G	A:PPK401	4.2	8.1	0.5
	CE1	A:HIS29	4.3	7.6	1.0
	O2G	A:PPK401	4.3	8.9	0.5
	CB	A:ASP31	4.3	7.1	1.0
	O	A:ALA259	4.4	11.5	1.0
	CB	A:ARG264	4.4	7.7	1.0
	O1A	A:PPK401	4.4	7.9	0.5
	O1B	A:PPK401	4.5	19.4	0.5
	CZ	A:ARG264	4.6	10.7	1.0
	NE	A:ARG264	4.6	12.0	1.0
	O	A:HOH516	4.7	12.0	0.5
	CE	A:LYS265	4.8	9.5	1.0
	O	A:ARG264	4.8	8.1	1.0
	NE2	A:HIS29	4.9	8.8	1.0
	CG	A:ASP258	5.0	14.6	0.8
	OD1	A:ASP258	5.0	15.1	0.8

Magnesium binding site 2 out of 2 in 8axz

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Magnesium Binding Sites List in 8axz

Magnesium binding site 2 out of 2 in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mg403 b:6.8 occ:0.50	O2A	A:PPK401	1.9	7.1	0.5
	O	A:HOH561	2.0	13.6	1.0
	O1G	A:PPK401	2.1	8.1	0.5
	O	A:HOH618	2.4	12.4	1.0
	PA	A:PPK401	3.3	4.9	0.5
	N3B	A:PPK401	3.4	11.8	0.5
	PG	A:PPK401	3.4	8.8	0.5
	NZ	A:LYS265	3.7	9.6	1.0
	O3A	A:PPK401	3.7	7.7	0.5
	OE2	A:GLU23	4.0	10.3	1.0
	O	A:HOH562	4.0	11.9	1.0
	O4A	A:PPK401	4.1	4.7	0.5
	NZ	A:LYS181	4.1	11.2	1.0
	O1A	A:PPK401	4.2	7.9	0.5
	O3G	A:PPK401	4.3	6.2	0.5
	O	A:HOH614	4.3	9.2	1.0
	PB	A:PPK401	4.4	17.4	0.5
	O2G	A:PPK401	4.4	8.9	0.5
	CE	A:LYS265	4.4	9.5	1.0
	OE1	A:GLU23	4.6	11.3	1.0
	CD	A:GLU23	4.8	11.2	1.0
	O	A:HOH516	5.0	12.0	0.5

Reference:

A.Nawrotek, L.Vuillard, L.Miallau. Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono-Aminophosphonic Acid. To Be Published.

Page generated: Thu Oct 3 19:05:51 2024

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