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Atomistry » Magnesium » PDB 8srd-8sy7 » 8stu | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 8srd-8sy7 » 8stu » |
Magnesium in PDB 8stu: Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C, V106A) Variant in Complex with 8-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)-4-Fluorophenoxy)-6-Fluoroindolizine-2-Carbonitrile (JLJ578), A Non-Nucleoside InhibitorEnzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C, V106A) Variant in Complex with 8-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)-4-Fluorophenoxy)-6-Fluoroindolizine-2-Carbonitrile (JLJ578), A Non-Nucleoside Inhibitor
All present enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C, V106A) Variant in Complex with 8-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)-4-Fluorophenoxy)-6-Fluoroindolizine-2-Carbonitrile (JLJ578), A Non-Nucleoside Inhibitor:
2.7.7.49; 2.7.7.7; 3.1.26.13; Protein crystallography data
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C, V106A) Variant in Complex with 8-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)-4-Fluorophenoxy)-6-Fluoroindolizine-2-Carbonitrile (JLJ578), A Non-Nucleoside Inhibitor, PDB code: 8stu
was solved by
K.Hollander,
W.L.Jorgensen,
K.S.Anderson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8stu:
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C, V106A) Variant in Complex with 8-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)-4-Fluorophenoxy)-6-Fluoroindolizine-2-Carbonitrile (JLJ578), A Non-Nucleoside Inhibitor also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C, V106A) Variant in Complex with 8-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)-4-Fluorophenoxy)-6-Fluoroindolizine-2-Carbonitrile (JLJ578), A Non-Nucleoside Inhibitor
(pdb code 8stu). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C, V106A) Variant in Complex with 8-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)-4-Fluorophenoxy)-6-Fluoroindolizine-2-Carbonitrile (JLJ578), A Non-Nucleoside Inhibitor, PDB code: 8stu: Magnesium binding site 1 out of 1 in 8stuGo back to![]() ![]()
Magnesium binding site 1 out
of 1 in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C, V106A) Variant in Complex with 8-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin- 1(2H)-Yl)Ethoxy)-4-Fluorophenoxy)-6-Fluoroindolizine-2-Carbonitrile (JLJ578), A Non-Nucleoside Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
K.Hollander,
A.H.Chan,
K.M.Frey,
O.Hunker,
J.A.Ippolito,
K.A.Spasov,
Y.J.Yeh,
W.L.Jorgensen,
Y.C.Ho,
K.S.Anderson.
Exploring Novel Hiv-1 Reverse Transcriptase Inhibitors with Drug Resistant Mutants: A Double Mutant Surprise. Protein Sci. E4814 2023.
Page generated: Fri Aug 15 16:00:38 2025
ISSN: ESSN 1469-896X PubMed: 37861472 DOI: 10.1002/PRO.4814 |
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