Magnesium in PDB 9gz2: Beta-Cardiac Heavy Meromyosin Motor Domain in the Primed State Complexed to Mavacamten

The binding sites of Magnesium atom in the Beta-Cardiac Heavy Meromyosin Motor Domain in the Primed State Complexed to Mavacamten (pdb code 9gz2). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Beta-Cardiac Heavy Meromyosin Motor Domain in the Primed State Complexed to Mavacamten, PDB code: 9gz2:

Magnesium binding site 1 out of 1 in the Beta-Cardiac Heavy Meromyosin Motor Domain in the Primed State Complexed to Mavacamten


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Beta-Cardiac Heavy Meromyosin Motor Domain in the Primed State Complexed to Mavacamten within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1201 b:42.4 occ:1.00 OG1 A:THR185 2.1 38.6 1.0 O1 A:PO41203 2.1 50.5 1.0 O2B A:ADP1202 2.2 41.8 1.0 OG A:SER242 3.3 40.6 1.0 CB A:SER242 3.3 40.6 1.0 PB A:ADP1202 3.4 41.8 1.0 CB A:THR185 3.5 38.6 1.0 P A:PO41203 3.5 50.5 1.0 N A:SER242 3.6 40.6 1.0 O3B A:ADP1202 3.6 41.8 1.0 O4 A:PO41203 3.9 50.5 1.0 OD1 A:ASP461 4.0 41.4 1.0 CA A:SER242 4.1 40.6 1.0 O2 A:PO41203 4.2 50.5 1.0 CG2 A:THR185 4.2 38.6 1.0 N A:THR185 4.3 38.6 1.0 O3A A:ADP1202 4.3 41.8 1.0 CA A:THR185 4.4 38.6 1.0 O2A A:ADP1202 4.5 41.8 1.0 O1B A:ADP1202 4.5 41.8 1.0 O A:ASN240 4.5 42.1 1.0 O3 A:PO41203 4.5 50.5 1.0 C A:SER241 4.6 41.7 1.0 OD2 A:ASP461 4.7 41.4 1.0 PA A:ADP1202 4.7 41.8 1.0 CG A:ASP461 4.8 41.4 1.0 CA A:SER241 4.8 41.7 1.0 O A:SER242 4.9 40.6 1.0 O1A A:ADP1202 4.9 41.8 1.0 CB A:LYS184 5.0 38.6 1.0

S.N.Mcmillan, J.R.T.Pitts, B.Barua, D.A.Winkelmann, C.A.Scarff. Mavacamten Inhibits Myosin Activity By Stabilising the Myosin Interacting-Heads Motif and Stalling Motor Force Generation. Biorxiv 2025.
ISSN: ISSN 2692-8205
PubMed: 39990378
DOI: 10.1101/2025.02.12.637875