Magnesium in PDB 1uj2: Crystal Structure of Human Uridine-Cytidine Kinase 2 Complexed with Products, Cmp and Adp

All present enzymatic activity of Crystal Structure of Human Uridine-Cytidine Kinase 2 Complexed with Products, Cmp and Adp:
2.7.1.48;

The structure of Crystal Structure of Human Uridine-Cytidine Kinase 2 Complexed with Products, Cmp and Adp, PDB code: 1uj2 was solved by N.N.Suzuki, K.Koizumi, M.Fukushima, A.Matsuda, F.Inagaki, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.40 / 1.80
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	89.022, 109.714, 64.845, 90.00, 95.32, 90.00
R / Rfree (%)	19 / 21.7

The binding sites of Magnesium atom in the Crystal Structure of Human Uridine-Cytidine Kinase 2 Complexed with Products, Cmp and Adp (pdb code 1uj2). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Human Uridine-Cytidine Kinase 2 Complexed with Products, Cmp and Adp, PDB code: 1uj2:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Crystal Structure of Human Uridine-Cytidine Kinase 2 Complexed with Products, Cmp and Adp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Human Uridine-Cytidine Kinase 2 Complexed with Products, Cmp and Adp within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg2303 b:26.6 occ:1.00 O A:HOH2467 2.1 53.7 1.0 O1P A:C5P2301 2.3 35.8 1.0 O2B A:ADP2302 2.3 27.2 1.0 O A:HOH2318 2.4 25.3 1.0 OG A:SER34 2.4 28.8 1.0 O A:HOH2519 2.5 54.7 1.0 O3B A:ADP2302 2.8 25.9 1.0 O2A A:ADP2302 3.1 41.0 1.0 PB A:ADP2302 3.1 25.7 1.0 CB A:SER34 3.5 28.3 1.0 P A:C5P2301 3.5 34.6 1.0 O3P A:C5P2301 3.7 32.9 1.0 O3A A:ADP2302 3.9 26.4 1.0 PA A:ADP2302 4.1 39.4 1.0 O1B A:ADP2302 4.3 22.6 1.0 NH1 A:ARG169 4.3 27.1 1.0 O2P A:C5P2301 4.4 33.7 1.0 N A:SER34 4.4 24.8 1.0 CA A:SER34 4.5 25.0 1.0 O A:HOH2452 4.7 59.1 1.0 O5' A:C5P2301 4.7 32.8 1.0 NH2 A:ARG174 4.7 35.2 1.0 O A:HOH2471 4.7 54.8 1.0 OE2 A:GLU135 4.7 25.7 1.0 OE1 A:GLU135 4.8 28.0 1.0 NZ A:LYS33 5.0 22.9 1.0 OD2 A:ASP62 5.0 21.5 0.5 O1A A:ADP2302 5.0 28.6 1.0

Magnesium binding site 2 out of 2 in the Crystal Structure of Human Uridine-Cytidine Kinase 2 Complexed with Products, Cmp and Adp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Human Uridine-Cytidine Kinase 2 Complexed with Products, Cmp and Adp within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1303 b:21.2 occ:1.00 O B:HOH1502 2.1 42.8 1.0 O1P B:C5P1301 2.2 31.3 1.0 O B:HOH1388 2.2 38.0 1.0 O2B B:ADP1302 2.3 30.0 1.0 OG B:SER34 2.5 27.7 1.0 O B:HOH1469 2.5 51.6 1.0 O3B B:ADP1302 2.9 29.5 1.0 PB B:ADP1302 3.2 28.5 1.0 O2A B:ADP1302 3.4 38.9 1.0 P B:C5P1301 3.5 31.3 1.0 CB B:SER34 3.6 26.2 1.0 O3P B:C5P1301 3.7 30.1 1.0 NH1 B:ARG169 4.0 30.6 1.0 O3A B:ADP1302 4.1 31.1 1.0 NH2 B:ARG174 4.2 35.7 1.0 O1B B:ADP1302 4.3 28.1 1.0 PA B:ADP1302 4.4 40.5 1.0 N B:SER34 4.4 27.1 1.0 O2P B:C5P1301 4.4 32.7 1.0 OD2 B:ASP62 4.5 28.2 0.5 OE2 B:GLU135 4.5 28.6 1.0 O B:HOH1494 4.5 53.2 1.0 O5' B:C5P1301 4.5 29.7 1.0 OE1 B:GLU135 4.6 30.6 1.0 CA B:SER34 4.6 27.5 1.0 NZ B:LYS33 4.8 25.1 1.0 CD B:GLU135 4.9 30.5 1.0 CE B:LYS33 5.0 25.0 1.0

N.N.Suzuki, K.Koizumi, M.Fukushima, A.Matsuda, F.Inagaki. Structural Basis For the Specificity, Catalysis, and Regulation of Human Uridine-Cytidine Kinase Structure V. 12 751 2004.
ISSN: ISSN 0969-2126
PubMed: 15130468
DOI: 10.1016/J.STR.2004.02.038