Magnesium in PDB 1xc9: Structure of A High-Fidelity Polymerase Bound to A Benzo[A]Pyrene Adduct That Blocks Replication

Enzymatic activity of Structure of A High-Fidelity Polymerase Bound to A Benzo[A]Pyrene Adduct That Blocks Replication

All present enzymatic activity of Structure of A High-Fidelity Polymerase Bound to A Benzo[A]Pyrene Adduct That Blocks Replication:
2.7.7.7;

Protein crystallography data

The structure of Structure of A High-Fidelity Polymerase Bound to A Benzo[A]Pyrene Adduct That Blocks Replication, PDB code: 1xc9 was solved by G.W.Hsu, X.Huang, N.P.Luneva, N.E.Geacintov, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	42.76 / 1.90
*Space group*	P 2₁ 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	88.752, 93.733, 104.512, 90.00, 90.00, 90.00
*R / R_free (%)*	22.1 / 25.5

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Structure of A High-Fidelity Polymerase Bound to A Benzo[A]Pyrene Adduct That Blocks Replication (pdb code 1xc9). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Structure of A High-Fidelity Polymerase Bound to A Benzo[A]Pyrene Adduct That Blocks Replication, PDB code: 1xc9:

Magnesium binding site 1 out of 1 in 1xc9

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Magnesium Binding Sites List in 1xc9

Magnesium binding site 1 out of 1 in the Structure of A High-Fidelity Polymerase Bound to A Benzo[A]Pyrene Adduct That Blocks Replication

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of A High-Fidelity Polymerase Bound to A Benzo[A]Pyrene Adduct That Blocks Replication within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mg920 b:49.5 occ:1.00	O	A:HOH2784	2.8	24.5	1.0
	O	A:TYR654	3.0	21.7	1.0
	OD2	A:ASP653	3.3	32.4	1.0
	O	A:HOH2786	3.6	26.9	1.0
	O	A:HOH2788	3.6	32.5	1.0
	C	A:TYR654	4.2	20.5	1.0
	CG	A:ASP653	4.2	28.3	1.0
	O	A:HOH2857	4.3	47.5	1.0
	CB	A:ASP653	4.3	24.5	1.0
	O	A:HOH2518	4.6	52.8	1.0
	CB	A:ASP830	4.7	23.9	1.0
	CA	A:SER655	4.7	20.9	1.0
	OD2	A:ASP830	4.8	25.5	1.0
	N	A:GLN656	4.9	19.2	1.0
	N	A:TYR654	4.9	20.1	1.0
	N	A:SER655	4.9	19.5	1.0
	O3'	B:DC29	5.0	43.3	1.0

Reference:

G.W.Hsu, X.Huang, N.P.Luneva, N.E.Geacintov, L.S.Beese. Structure of A High Fidelity Dna Polymerase Bound to A Benzo[A]Pyrene Adduct That Blocks Replication J.Biol.Chem. V. 280 3764 2005.
ISSN: ISSN 0021-9258
PubMed: 15548515
DOI: 10.1074/JBC.M411276200

Page generated: Tue Aug 13 17:30:30 2024

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