Magnesium in PDB 2ad5: Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution.

Enzymatic activity of Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution.

All present enzymatic activity of Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution.:
6.3.4.2;

Protein crystallography data

The structure of Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution., PDB code: 2ad5 was solved by J.A.Endrizzi, H.Kim, P.M.Anderson, E.P.Baldwin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 2.80
*Space group*	P 2₁ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	163.270, 106.380, 130.470, 90.00, 90.00, 90.00
*R / R_free (%)*	n/a / n/a

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution. (pdb code 2ad5). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution., PDB code: 2ad5:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 2ad5

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Magnesium Binding Sites List in 2ad5

Magnesium binding site 1 out of 2 in the Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution.

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Mg701 b:32.8 occ:1.00	OE2	A:GLU140	2.1	52.3	1.0
	O1B	A:ADP601	2.1	50.4	1.0
	OD2	A:ASP72	2.3	70.5	1.0
	CD	A:GLU140	3.0	59.9	1.0
	OE1	A:GLU140	3.3	57.9	1.0
	CG	A:ASP72	3.3	62.6	1.0
	NZ	A:LYS40	3.4	76.5	1.0
	N	A:GLY19	3.4	43.2	1.0
	PB	A:ADP601	3.5	57.1	1.0
	OD1	A:ASP72	3.6	67.2	1.0
	CA	A:GLY19	3.7	43.4	1.0
	CE	A:LYS40	3.8	47.3	1.0
	O2A	A:ADP601	3.8	0.0	1.0
	O	A:HOH784	3.8	74.8	1.0
	O2B	A:ADP601	4.1	42.2	1.0
	CB	A:LYS18	4.2	40.4	1.0
	O3B	A:ADP601	4.3	56.3	1.0
	CG	A:GLU140	4.3	41.2	1.0
	CE	A:LYS18	4.4	40.1	1.0
	C	A:LYS18	4.5	44.6	1.0
	O3A	A:ADP601	4.5	89.1	1.0
	CD	A:LYS40	4.5	39.1	1.0
	PA	A:ADP601	4.6	98.9	1.0
	CB	A:ASP72	4.6	44.3	1.0
	NZ	A:LYS18	4.7	56.8	1.0
	O	A:HOH721	4.8	83.1	1.0
	CA	A:LYS18	4.8	39.7	1.0
	N	A:LYS18	4.8	41.1	1.0
	O1A	A:ADP601	4.9	78.0	1.0
	CG	A:LYS18	4.9	35.6	1.0

Magnesium binding site 2 out of 2 in 2ad5

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Magnesium Binding Sites List in 2ad5

Magnesium binding site 2 out of 2 in the Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution.

Mono view

Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Mechanisms of Feedback Regulation and Drug Resistance of Ctp Synthetases: Structure of the E. Coli Ctps/Ctp Complex at 2.8- Angstrom Resolution. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Mg1701 b:45.7 occ:1.00	OE2	B:GLU140	1.9	53.1	1.0
	O1B	B:ADP1601	2.0	61.1	1.0
	OD2	B:ASP72	2.2	63.8	1.0
	CD	B:GLU140	2.9	57.0	1.0
	CG	B:ASP72	3.2	59.6	1.0
	OE1	B:GLU140	3.2	59.2	1.0
	N	B:GLY19	3.4	43.3	1.0
	PB	B:ADP1601	3.5	60.1	1.0
	OD1	B:ASP72	3.6	68.1	1.0
	CA	B:GLY19	3.6	43.2	1.0
	O	B:HOH1741	3.8	58.0	1.0
	CE	B:LYS40	3.8	43.5	1.0
	CG	B:LYS18	4.1	48.2	1.0
	O2A	B:ADP1601	4.1	0.0	1.0
	O3B	B:ADP1601	4.2	48.3	1.0
	CG	B:GLU140	4.2	42.8	1.0
	NZ	B:LYS40	4.2	48.3	1.0
	O2B	B:ADP1601	4.2	48.4	1.0
	C	B:LYS18	4.3	46.8	1.0
	O3A	B:ADP1601	4.4	78.8	1.0
	CB	B:ASP72	4.4	40.0	1.0
	O1A	B:ADP1601	4.5	83.4	1.0
	PA	B:ADP1601	4.5	91.8	1.0
	CD	B:LYS40	4.6	42.2	1.0
	NZ	B:LYS18	4.7	60.8	1.0
	CE	B:LYS18	4.7	49.0	1.0
	CA	B:LYS18	4.8	44.3	1.0
	CB	B:LYS18	4.8	46.7	1.0
	N	B:LYS18	4.9	44.4	1.0
	CD	B:LYS18	5.0	42.6	1.0

Reference:

J.A.Endrizzi, H.Kim, P.M.Anderson, E.P.Baldwin. Mechanisms of Product Feedback Regulation and Drug Resistance in Cytidine Triphosphate Synthetases From the Structure of A Ctp-Inhibited Complex(,). Biochemistry V. 44 13491 2005.
ISSN: ISSN 0006-2960
PubMed: 16216072
DOI: 10.1021/BI051282O

Page generated: Tue Aug 13 21:28:00 2024

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