Atomistry » Magnesium » PDB 2bt1-2c3u » 2c19
Atomistry »
  Magnesium »
    PDB 2bt1-2c3u »
      2c19 »

Magnesium in PDB 2c19: 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa

Enzymatic activity of 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa

All present enzymatic activity of 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa:
4.2.1.24;

Protein crystallography data

The structure of 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa, PDB code: 2c19 was solved by F.Frere, M.Nentwich, S.Gacond, D.W.Heinz, R.Neier, N.Frankenberg-Dinkel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 89.80 / 2.05
Space group P 4 21 2
Cell size a, b, c (Å), α, β, γ (°) 127.203, 127.203, 85.848, 90.00, 90.00, 90.00
R / Rfree (%) 14.4 / 20.1

Other elements in 2c19:

The structure of 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa also contains other interesting chemical elements:

Sodium (Na) 2 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa (pdb code 2c19). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa, PDB code: 2c19:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 2c19

Go back to Magnesium Binding Sites List in 2c19
Magnesium binding site 1 out of 2 in the 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg1336

b:14.9
occ:1.00
O A:HOH2268 2.0 11.8 1.0
OE1 A:GLU245 2.0 14.6 1.0
O A:HOH2267 2.1 12.2 1.0
O A:HOH2270 2.2 11.8 1.0
O A:HOH2217 2.2 15.3 1.0
O A:HOH2271 2.3 15.2 1.0
CD A:GLU245 3.1 14.2 1.0
OE2 A:GLU245 3.5 11.8 1.0
NH1 A:ARG181 3.7 12.2 1.0
OD1 A:ASP249 3.8 15.4 1.0
O A:HOH2275 4.0 11.7 1.0
O A:HOH2216 4.1 7.9 0.8
O A:HOH2276 4.2 11.6 1.0
O A:MET178 4.2 12.9 1.0
OD2 A:ASP249 4.3 14.1 1.0
CG A:ASP249 4.4 13.5 1.0
CG A:GLU245 4.4 12.5 1.0
OD1 A:ASP179 4.4 14.2 1.0
O A:SER203 4.6 13.4 1.0
CA A:ASP179 4.6 12.9 1.0
O A:GLU245 4.6 10.6 1.0
O B:HOH2035 4.7 13.3 1.0
CB A:GLU245 4.7 11.8 1.0
CA A:GLU245 4.8 11.8 1.0
SD A:MET177 4.9 13.1 1.0
C A:MET178 5.0 12.9 1.0
N A:GLY180 5.0 13.2 1.0

Magnesium binding site 2 out of 2 in 2c19

Go back to Magnesium Binding Sites List in 2c19
Magnesium binding site 2 out of 2 in the 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of 5-(4-Carboxy-2-Oxo-Butylsulfanyl)-4-Oxo-Pentanoic Acid Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg1336

b:13.9
occ:1.00
OE1 B:GLU245 2.1 11.7 1.0
O B:HOH2281 2.1 11.2 1.0
O B:HOH2284 2.1 13.3 1.0
O B:HOH2280 2.2 15.8 1.0
O B:HOH2240 2.2 14.2 1.0
O B:HOH2283 2.2 14.4 1.0
CD B:GLU245 3.1 13.2 1.0
OE2 B:GLU245 3.4 13.1 1.0
NH1 B:ARG181 3.7 13.7 1.0
OD1 B:ASP249 3.8 14.5 1.0
O B:HOH2239 4.1 12.4 1.0
O B:HOH2286 4.1 12.7 1.0
O B:HOH2288 4.2 13.0 1.0
OD2 B:ASP249 4.3 15.0 1.0
O B:MET178 4.3 15.6 1.0
CG B:ASP249 4.4 14.3 1.0
CG B:GLU245 4.4 12.5 1.0
O B:SER203 4.5 13.7 1.0
OD1 B:ASP179 4.6 15.1 1.0
O A:HOH2040 4.6 14.1 1.0
CA B:ASP179 4.7 15.0 1.0
CB B:GLU245 4.7 12.1 1.0
O B:GLU245 4.8 13.4 1.0
CA B:GLU245 4.9 12.6 1.0
SD B:MET177 4.9 14.1 1.0
CE B:MET177 4.9 9.1 1.0
N B:GLY180 5.0 15.0 1.0

Reference:

F.Frere, M.Nentwich, S.Gacond, D.W.Heinz, R.Neier, N.Frankenberg-Dinkel. Probing the Active Site of Pseudomonas Aeruginosa Porphobilinogen Synthase Using Newly Developed Inhibitors. Biochemistry V. 45 8243 2006.
ISSN: ISSN 0006-2960
PubMed: 16819823
DOI: 10.1021/BI052611F
Page generated: Mon Dec 14 07:18:05 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy