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Magnesium in PDB 3osn: Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota

Enzymatic activity of Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota

All present enzymatic activity of Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota:
2.7.7.7;

Protein crystallography data

The structure of Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota, PDB code: 3osn was solved by M.G.Pence, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.62 / 1.90
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 97.973, 97.973, 202.757, 90.00, 90.00, 120.00
R / Rfree (%) 20.8 / 24.1

Other elements in 3osn:

The structure of Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota also contains other interesting chemical elements:

Sodium (Na) 1 atom

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota (pdb code 3osn). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota, PDB code: 3osn:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 3osn

Go back to Magnesium Binding Sites List in 3osn
Magnesium binding site 1 out of 2 in the Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg422

b:31.0
occ:0.50
O A:LEU35 2.2 28.0 1.0
OD2 A:ASP34 2.3 27.7 1.0
O2A A:TTP421 2.4 31.2 0.5
O1B A:TTP421 2.6 13.5 0.5
O2G A:TTP421 2.8 38.6 1.0
CG A:ASP126 3.2 32.8 1.0
OD1 A:ASP126 3.2 36.1 1.0
MG A:MG424 3.3 30.9 0.5
C A:LEU35 3.4 25.6 1.0
OD2 A:ASP126 3.5 31.6 1.0
PB A:TTP421 3.5 33.0 0.5
CG A:ASP34 3.6 27.1 1.0
N A:LEU35 3.6 22.5 1.0
PA A:TTP421 3.7 33.4 0.5
O3A A:TTP421 3.8 32.8 0.5
CB A:ASP126 3.8 27.6 1.0
C A:ASP34 4.0 24.1 1.0
CA A:LEU35 4.0 24.7 1.0
O A:HOH505 4.1 27.1 1.0
PG A:TTP421 4.1 40.9 1.0
O A:ASP126 4.1 24.1 1.0
O3B A:TTP421 4.2 33.5 0.5
OD1 A:ASP34 4.2 27.8 1.0
O A:HOH483 4.2 24.8 1.0
N A:ASP36 4.5 25.5 1.0
O5' A:TTP421 4.5 33.0 0.5
CA A:ASP34 4.5 21.0 1.0
O3G A:TTP421 4.5 35.5 1.0
O A:ASP34 4.6 22.2 1.0
CB A:ASP34 4.6 24.7 1.0
CB A:LEU35 4.6 25.3 1.0
N A:CYS37 4.7 26.9 1.0
CA A:ASP36 4.7 28.9 1.0
C A:ASP126 4.7 23.2 1.0
C A:ASP36 4.8 28.9 1.0
O1A A:TTP421 4.9 32.0 0.5
CG A:GLU127 4.9 25.2 1.0
CA A:ASP126 4.9 24.8 1.0
O2B A:TTP421 5.0 21.9 0.5
N A:PHE38 5.0 23.5 1.0

Magnesium binding site 2 out of 2 in 3osn

Go back to Magnesium Binding Sites List in 3osn
Magnesium binding site 2 out of 2 in the Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structural Basis For Proficient Incorporation of Dttp Opposite O6- Methylguanine By Human Dna Polymerase Iota within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg424

b:30.9
occ:0.50
O2A A:TTP421 2.2 31.2 0.5
OE2 A:GLU127 2.2 32.4 1.0
O A:HOH483 2.7 24.8 1.0
OD1 A:ASP34 2.9 27.8 1.0
OD2 A:ASP34 2.9 27.7 1.0
CD A:GLU127 3.2 27.9 1.0
CG A:ASP34 3.2 27.1 1.0
PA A:TTP421 3.2 33.4 0.5
MG A:MG422 3.3 31.0 0.5
CG A:GLU127 3.5 25.2 1.0
O1A A:TTP421 3.5 32.0 0.5
OD2 A:ASP126 3.6 31.6 1.0
O2G A:TTP421 4.0 38.6 1.0
C3' B:DOC13 4.2 30.1 1.0
OE1 A:GLU127 4.3 28.4 1.0
O3A A:TTP421 4.3 32.8 0.5
CG A:ASP126 4.3 32.8 1.0
C4' B:DOC13 4.4 31.1 1.0
O5' A:TTP421 4.4 33.0 0.5
OD1 A:ASP126 4.5 36.1 1.0
CB A:ASP34 4.6 24.7 1.0
C5' B:DOC13 4.8 33.0 1.0
O A:HOH582 5.0 28.3 1.0

Reference:

M.G.Pence, J.Y.Choi, M.Egli, F.P.Guengerich. Structural Basis For Proficient Incorporation of Dttp Opposite O6-Methylguanine By Human Dna Polymerase {Iota}. J.Biol.Chem. V. 285 40666 2010.
ISSN: ISSN 0021-9258
PubMed: 20961860
DOI: 10.1074/JBC.M110.183665
Page generated: Mon Dec 14 08:36:41 2020

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