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Magnesium in PDB 4f0y: Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo

Enzymatic activity of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo

All present enzymatic activity of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo:
2.3.1.82;

Protein crystallography data

The structure of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo, PDB code: 4f0y was solved by P.J.Stogios, E.Evdokimova, A.Dong, G.Minasov, V.Yim, P.Courvalin, A.Savchenko, W.F.Anderson, Center For Structural Genomics Ofinfectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.07 / 2.56
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 37.963, 44.018, 46.576, 83.19, 87.44, 72.65
R / Rfree (%) 18.1 / 24

Other elements in 4f0y:

The structure of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo (pdb code 4f0y). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo, PDB code: 4f0y:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 4f0y

Go back to Magnesium Binding Sites List in 4f0y
Magnesium binding site 1 out of 2 in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg201

b:37.7
occ:1.00
 O A:HOH342 2.1 63.2 1.0
O A:HOH341 2.1 39.7 1.0
O A:ASP114 2.1 21.1 1.0
O A:HOH343 2.1 47.5 1.0
O A:HOH340 2.1 31.1 1.0
OD1 A:ASP114 2.1 25.3 1.0
C A:ASP114 3.1 26.5 1.0
CG A:ASP114 3.3 27.1 1.0
N A:ASP114 3.8 30.4 1.0
CA A:ASP114 3.8 28.8 1.0
O A:GLU78 3.9 23.8 1.0
N A:ALA115 4.0 29.3 1.0
O A:HOH316 4.1 15.2 1.0
CB A:ASP114 4.1 27.9 1.0
OG A:SER113 4.2 28.6 1.0
OD2 A:ASP114 4.3 28.4 1.0
CA A:ALA115 4.3 30.6 1.0
O A:HOH336 4.3 29.5 1.0
O A:LEU77 4.3 19.0 1.0
C A:GLU78 4.8 25.2 1.0
CB A:ALA115 4.9 29.9 1.0
C A:SER113 5.0 31.2 1.0

Magnesium binding site 2 out of 2 in 4f0y

Go back to Magnesium Binding Sites List in 4f0y
Magnesium binding site 2 out of 2 in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg201

b:57.2
occ:1.00
 OD1 B:ASP114 2.0 29.9 1.0
O B:HOH339 2.1 43.2 1.0
O B:HOH337 2.1 32.9 1.0
O B:HOH333 2.1 24.8 1.0
O B:HOH336 2.1 23.6 1.0
O B:ASP114 2.1 30.3 1.0
CG B:ASP114 3.1 30.2 1.0
C B:ASP114 3.1 28.8 1.0
O B:GLU78 3.7 33.0 1.0
N B:ASP114 3.7 18.5 1.0
CA B:ASP114 3.8 24.0 1.0
OD2 B:ASP114 3.9 37.1 1.0
CB B:ASP114 4.1 26.9 1.0
O B:LEU77 4.2 25.0 1.0
N B:ALA115 4.2 25.7 1.0
O B:HOH338 4.2 29.8 1.0
OG B:SER113 4.4 20.6 1.0
C B:GLU78 4.5 34.0 1.0
CA B:ALA115 4.5 22.6 1.0
O B:HOH308 4.5 19.2 1.0
O B:HOH322 4.9 17.6 1.0
CE2 B:PHE76 4.9 27.7 1.0
C B:SER113 5.0 22.1 1.0

Reference:

P.J.Stogios, M.L.Kuhn, E.Evdokimova, M.Law, P.Courvalin, A.Savchenko. Structural and Biochemical Characterization of Acinetobacter Spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation Among Antibiotic Resistance Enzymes. Acs Infect Dis. V. 3 132 2017.
ISSN: ESSN 2373-8227
PubMed: 27785912
DOI: 10.1021/ACSINFECDIS.6B00058
Page generated: Fri Aug 16 14:40:00 2024

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