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Atomistry » Magnesium » PDB 4fs5-4g7f » 4g2l | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 4fs5-4g7f » 4g2l » |
Magnesium in PDB 4g2l: Human PDE9 in Complex with Selective CompoundEnzymatic activity of Human PDE9 in Complex with Selective Compound
All present enzymatic activity of Human PDE9 in Complex with Selective Compound:
3.1.4.35; Protein crystallography data
The structure of Human PDE9 in Complex with Selective Compound, PDB code: 4g2l
was solved by
S.Liu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4g2l:
The structure of Human PDE9 in Complex with Selective Compound also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Human PDE9 in Complex with Selective Compound
(pdb code 4g2l). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Human PDE9 in Complex with Selective Compound, PDB code: 4g2l: Jump to Magnesium binding site number: 1; 2; Magnesium binding site 1 out of 2 in 4g2lGo back to Magnesium Binding Sites List in 4g2l
Magnesium binding site 1 out
of 2 in the Human PDE9 in Complex with Selective Compound
Mono view Stereo pair view
Magnesium binding site 2 out of 2 in 4g2lGo back to Magnesium Binding Sites List in 4g2l
Magnesium binding site 2 out
of 2 in the Human PDE9 in Complex with Selective Compound
Mono view Stereo pair view
Reference:
M.M.Claffey,
C.J.Helal,
P.R.Verhoest,
Z.Kang,
K.S.Fors,
S.Jung,
J.Zhong,
M.W.Bundesmann,
X.Hou,
S.Lui,
R.J.Kleiman,
M.Vanase-Frawley,
A.W.Schmidt,
F.Menniti,
C.J.Schmidt,
W.E.Hoffman,
M.Hajos,
L.Mcdowell,
R.E.O'connor,
M.Macdougall-Murphy,
K.R.Fonseca,
S.L.Becker,
F.R.Nelson,
S.Liras.
Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, in Vivo Active Phosphodiesterase 9A Inhibitors. J.Med.Chem. V. 55 9055 2012.
Page generated: Mon Dec 14 15:54:34 2020
ISSN: ISSN 0022-2623 PubMed: 23025719 DOI: 10.1021/JM3009635 |
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