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Magnesium in PDB 4ja7: Rat PP5 Co-Crystallized with P5SA-2

Enzymatic activity of Rat PP5 Co-Crystallized with P5SA-2

All present enzymatic activity of Rat PP5 Co-Crystallized with P5SA-2:
3.1.3.16;

Protein crystallography data

The structure of Rat PP5 Co-Crystallized with P5SA-2, PDB code: 4ja7 was solved by V.Haslbeck, M.Helmuth, F.Alte, G.Popowicz, W.Schmidt, M.Weiwad, G.Fischer, G.Gemmecker, M.Sattler, F.Striggow, M.Groll, K.Richter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.00
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 51.100, 51.100, 365.670, 90.00, 90.00, 90.00
R / Rfree (%) 21.4 / 26.2

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Rat PP5 Co-Crystallized with P5SA-2 (pdb code 4ja7). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Rat PP5 Co-Crystallized with P5SA-2, PDB code: 4ja7:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in 4ja7

Go back to Magnesium Binding Sites List in 4ja7
Magnesium binding site 1 out of 2 in the Rat PP5 Co-Crystallized with P5SA-2


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Rat PP5 Co-Crystallized with P5SA-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg501

b:34.8
occ:1.00
NE2 A:HIS352 2.0 34.6 1.0
ND1 A:HIS427 2.1 40.6 1.0
OD1 A:ASN303 2.1 42.6 1.0
OD2 A:ASP271 2.2 38.6 1.0
MG A:MG502 2.8 43.0 1.0
CE1 A:HIS352 2.9 33.6 1.0
O A:HOH700 3.0 50.9 1.0
CE1 A:HIS427 3.0 42.1 1.0
CD2 A:HIS352 3.1 29.5 1.0
CG A:ASN303 3.2 47.3 1.0
CG A:HIS427 3.2 39.2 1.0
CG A:ASP271 3.3 36.3 1.0
CA A:HIS427 3.5 36.4 1.0
ND2 A:ASN303 3.7 44.9 1.0
CB A:HIS427 3.7 36.5 1.0
O A:HOH610 3.7 38.2 1.0
OD1 A:ASP271 3.7 33.4 1.0
OD2 A:ASP242 3.7 37.8 1.0
O A:HIS427 3.9 42.5 1.0
ND1 A:HIS352 4.1 31.4 1.0
NE2 A:HIS427 4.2 43.6 1.0
C A:HIS427 4.2 42.3 1.0
CG A:HIS352 4.2 33.5 1.0
CD2 A:HIS427 4.3 38.8 1.0
CD2 A:HIS304 4.5 40.7 1.0
CB A:ASP271 4.5 36.5 1.0
CB A:ASN303 4.5 36.8 1.0
N A:HIS427 4.5 33.5 1.0
CG A:ASP242 4.7 37.8 1.0
N A:ASN303 4.7 36.0 1.0
NE2 A:HIS244 4.7 42.2 1.0
OD1 A:ASP242 4.9 42.2 1.0
O A:LEU385 4.9 32.9 1.0

Magnesium binding site 2 out of 2 in 4ja7

Go back to Magnesium Binding Sites List in 4ja7
Magnesium binding site 2 out of 2 in the Rat PP5 Co-Crystallized with P5SA-2


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Rat PP5 Co-Crystallized with P5SA-2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg502

b:43.0
occ:1.00
NE2 A:HIS244 2.1 42.2 1.0
OD2 A:ASP271 2.1 38.6 1.0
OD2 A:ASP242 2.2 37.8 1.0
O A:HOH610 2.4 38.2 1.0
MG A:MG501 2.8 34.8 1.0
CE1 A:HIS244 2.9 39.5 1.0
CG A:ASP271 3.0 36.3 1.0
CD2 A:HIS244 3.2 37.1 1.0
CG A:ASP242 3.3 37.8 1.0
O A:HOH700 3.4 50.9 1.0
CB A:ASP271 3.4 36.5 1.0
CE1 A:HIS352 4.0 33.6 1.0
NE2 A:HIS352 4.0 34.6 1.0
OD1 A:ASP271 4.1 33.4 1.0
CB A:ASP242 4.1 35.8 1.0
CD2 A:HIS304 4.1 40.7 1.0
O A:HOH640 4.1 52.6 1.0
ND1 A:HIS244 4.1 40.8 1.0
OD1 A:ASP242 4.2 42.2 1.0
OD1 A:ASN303 4.2 42.6 1.0
O A:HIS427 4.3 42.5 1.0
CG A:HIS244 4.3 36.7 1.0
CA A:HIS427 4.5 36.4 1.0
ND1 A:HIS427 4.6 40.6 1.0
NE2 A:HIS304 4.6 42.5 1.0
OH A:TYR451 4.7 43.8 1.0
C A:HIS427 4.8 42.3 1.0
OE2 A:GLU76 4.8 70.0 1.0
CE1 A:PHE446 4.9 35.5 1.0
CA A:ASP271 4.9 37.9 1.0
CG A:HIS304 4.9 42.0 1.0

Reference:

V.Haslbeck, M.Helmuth, F.Alte, G.Popowicz, W.Schmidt, M.Weiwad, G.Fischer, G.Gemmecker, M.Sattler, F.Striggow, M.Groll, K.Richter. Selective Targeting of the Autoinhibition of PP5 Reduces Tau Phosphorylation in Mouse. To Be Published.
Page generated: Fri Aug 16 17:19:52 2024

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