Magnesium in PDB 5idz: Structure of Human Enolase 2 in Complex with (S)-(1-Hydroxy-2- Oxopiperidin-3-Yl)Phosphonate

All present enzymatic activity of Structure of Human Enolase 2 in Complex with (S)-(1-Hydroxy-2- Oxopiperidin-3-Yl)Phosphonate:
4.2.1.11;

The structure of Structure of Human Enolase 2 in Complex with (S)-(1-Hydroxy-2- Oxopiperidin-3-Yl)Phosphonate, PDB code: 5idz was solved by P.G.Leonard, F.L.Muller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	54.37 / 2.63
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.100, 108.740, 116.460, 90.00, 90.00, 90.00
R / Rfree (%)	16.2 / 21.8

The binding sites of Magnesium atom in the Structure of Human Enolase 2 in Complex with (S)-(1-Hydroxy-2- Oxopiperidin-3-Yl)Phosphonate (pdb code 5idz). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Structure of Human Enolase 2 in Complex with (S)-(1-Hydroxy-2- Oxopiperidin-3-Yl)Phosphonate, PDB code: 5idz:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Structure of Human Enolase 2 in Complex with (S)-(1-Hydroxy-2- Oxopiperidin-3-Yl)Phosphonate


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Human Enolase 2 in Complex with (S)-(1-Hydroxy-2- Oxopiperidin-3-Yl)Phosphonate within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg500 b:24.0 occ:1.00 OE2 A:GLU293 2.1 31.6 1.0 O A:HOH623 2.1 23.9 1.0 O08 A:6BM501 2.1 30.3 1.0 OD2 A:ASP318 2.1 26.2 1.0 OD2 A:ASP245 2.1 33.6 1.0 O07 A:6BM501 2.2 30.4 1.0 N01 A:6BM501 2.9 29.5 1.0 C06 A:6BM501 2.9 26.7 1.0 CG A:ASP245 3.1 32.1 1.0 CG A:ASP318 3.2 30.1 1.0 CD A:GLU293 3.3 26.7 1.0 OD1 A:ASP245 3.3 29.8 1.0 NZ A:LYS394 3.8 24.9 1.0 CB A:ASP318 3.8 25.4 1.0 NZ A:LYS343 4.0 33.7 1.0 OE1 A:GLU293 4.0 33.4 1.0 CD2 A:LEU341 4.1 22.1 1.0 OD1 A:ASP318 4.2 34.8 1.0 CG A:GLU293 4.2 23.8 1.0 OD2 A:ASP294 4.3 27.1 1.0 C02 A:6BM501 4.3 22.0 1.0 NE2 A:GLN166 4.3 32.8 1.0 C05 A:6BM501 4.3 29.4 1.0 CB A:ASP245 4.4 30.6 1.0 CE A:LYS343 4.7 21.4 1.0 CE A:LYS394 4.8 23.9 1.0

Magnesium binding site 2 out of 2 in the Structure of Human Enolase 2 in Complex with (S)-(1-Hydroxy-2- Oxopiperidin-3-Yl)Phosphonate


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Structure of Human Enolase 2 in Complex with (S)-(1-Hydroxy-2- Oxopiperidin-3-Yl)Phosphonate within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg500 b:32.0 occ:1.00 O08 B:6BM501 2.0 27.3 1.0 O B:HOH633 2.1 27.8 1.0 OE2 B:GLU293 2.1 38.9 1.0 OD1 B:ASP318 2.1 27.2 1.0 OD2 B:ASP245 2.1 37.8 1.0 O07 B:6BM501 2.2 39.8 1.0 C06 B:6BM501 2.8 33.4 1.0 N01 B:6BM501 2.8 29.2 1.0 CG B:ASP245 3.1 41.8 1.0 CD B:GLU293 3.2 33.8 1.0 CG B:ASP318 3.3 33.1 1.0 OD1 B:ASP245 3.3 29.5 1.0 NZ B:LYS394 3.9 24.0 1.0 OE1 B:GLU293 3.9 29.3 1.0 CB B:ASP318 3.9 36.7 1.0 OE1 B:GLN166 4.0 30.9 1.0 NZ B:LYS343 4.1 29.4 1.0 CG B:GLU293 4.2 33.5 1.0 C05 B:6BM501 4.2 30.2 1.0 OD2 B:ASP318 4.3 30.2 1.0 C02 B:6BM501 4.3 24.6 1.0 CD2 B:LEU341 4.4 23.6 1.0 CB B:ASP245 4.5 30.6 1.0 OD2 B:ASP294 4.6 37.1 1.0 OE2 B:GLU167 4.8 40.2 1.0 CE B:LYS394 4.9 24.4 1.0 CE B:LYS343 4.9 24.6 1.0

Y.H.Lin, N.Satani, N.Hammoudi, F.Felini, P.G.Leonard, D.Maxwell, T.Link, G.R.Lee, A.Bosajou, S.Duoli, J.R.Marszalek, Y.T.Sun, J.Mcmurray, P.J.Mandal, M.E.Difrancesco, B.Czako, A.Wang, W.Bornmann, R.A.Depinho, F.L.Muller. Pomhex, A Cell-Permeable Enolase Inhibitor For Collateral Lethality Targeting of ENO1-Deleted Glioblastoma To Be Published.