Magnesium in PDB 5svs: Anomalous MN2+ Signal Reveals A Divalent Cation-Binding Site in the Head Domain of the Atp-Gated Human P2X3 Ion Channel

The structure of Anomalous MN2+ Signal Reveals A Divalent Cation-Binding Site in the Head Domain of the Atp-Gated Human P2X3 Ion Channel, PDB code: 5svs was solved by S.E.Mansoor, W.Lu, W.Oosterheert, M.Shekhar, E.Tajkhorshid, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.78 / 4.03
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	120.200, 120.200, 236.240, 90.00, 90.00, 120.00
R / Rfree (%)	22.9 / 27.5

The structure of Anomalous MN2+ Signal Reveals A Divalent Cation-Binding Site in the Head Domain of the Atp-Gated Human P2X3 Ion Channel also contains other interesting chemical elements:

Sodium

(Na)

1 atom

The binding sites of Magnesium atom in the Anomalous MN2+ Signal Reveals A Divalent Cation-Binding Site in the Head Domain of the Atp-Gated Human P2X3 Ion Channel (pdb code 5svs). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Anomalous MN2+ Signal Reveals A Divalent Cation-Binding Site in the Head Domain of the Atp-Gated Human P2X3 Ion Channel, PDB code: 5svs:

Magnesium binding site 1 out of 1 in the Anomalous MN2+ Signal Reveals A Divalent Cation-Binding Site in the Head Domain of the Atp-Gated Human P2X3 Ion Channel


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Anomalous MN2+ Signal Reveals A Divalent Cation-Binding Site in the Head Domain of the Atp-Gated Human P2X3 Ion Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg404 b:0.2 occ:1.00 OD1 A:ASP158 3.1 0.3 1.0 OE1 A:GLU109 3.5 0.1 1.0 O A:GLU156 3.7 0.4 1.0 OE2 A:GLU109 3.9 0.6 1.0 CD A:GLU109 3.9 0.4 1.0 CG A:ASP158 4.2 0.3 1.0 OD2 A:ASP158 4.6 0.9 1.0 C A:GLU156 4.7 0.7 1.0 CB A:GLU111 4.7 0.6 1.0 CB A:GLU156 4.8 0.0 1.0

S.E.Mansoor, W.Lu, W.Oosterheert, M.Shekhar, E.Tajkhorshid, E.Gouaux. X-Ray Structures Define Human P2X3 Receptor Gating Cycle and Antagonist Action. Nature V. 538 66 2016.
ISSN: ESSN 1476-4687
PubMed: 27626375
DOI: 10.1038/NATURE19367