Magnesium in PDB 5svt: Anomalous Cs+ Signal Reveals the Site of Na+ Ion Entry to the Channel Pore of the Human P2X3 Ion Channel Through the Extracellular Fenestrations

The structure of Anomalous Cs+ Signal Reveals the Site of Na+ Ion Entry to the Channel Pore of the Human P2X3 Ion Channel Through the Extracellular Fenestrations, PDB code: 5svt was solved by S.E.Mansoor, W.Lu, W.Oosterheert, M.Shekhar, E.Tajkhorshid, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.73 / 3.79
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	119.950, 119.950, 236.410, 90.00, 90.00, 120.00
R / Rfree (%)	27.6 / 31.2

The structure of Anomalous Cs+ Signal Reveals the Site of Na+ Ion Entry to the Channel Pore of the Human P2X3 Ion Channel Through the Extracellular Fenestrations also contains other interesting chemical elements:

Sodium

(Na)

1 atom

The binding sites of Magnesium atom in the Anomalous Cs+ Signal Reveals the Site of Na+ Ion Entry to the Channel Pore of the Human P2X3 Ion Channel Through the Extracellular Fenestrations (pdb code 5svt). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Anomalous Cs+ Signal Reveals the Site of Na+ Ion Entry to the Channel Pore of the Human P2X3 Ion Channel Through the Extracellular Fenestrations, PDB code: 5svt:

Magnesium binding site 1 out of 1 in the Anomalous Cs+ Signal Reveals the Site of Na+ Ion Entry to the Channel Pore of the Human P2X3 Ion Channel Through the Extracellular Fenestrations


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Anomalous Cs+ Signal Reveals the Site of Na+ Ion Entry to the Channel Pore of the Human P2X3 Ion Channel Through the Extracellular Fenestrations within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg404 b:0.8 occ:1.00 OD1 A:ASP158 3.2 0.5 1.0 OE1 A:GLU109 3.7 0.7 1.0 O A:GLU156 3.9 0.6 1.0 OE2 A:GLU109 4.0 0.9 1.0 CD A:GLU109 4.1 0.2 1.0 CG A:ASP158 4.4 0.0 1.0 CB A:GLU156 4.6 1.0 1.0 OE1 A:GLU156 4.7 1.0 1.0 C A:GLU156 4.7 0.7 1.0 CB A:GLU111 4.8 0.7 1.0 OD2 A:ASP158 4.9 0.2 1.0

S.E.Mansoor, W.Lu, W.Oosterheert, M.Shekhar, E.Tajkhorshid, E.Gouaux. X-Ray Structures Define Human P2X3 Receptor Gating Cycle and Antagonist Action. Nature V. 538 66 2016.
ISSN: ESSN 1476-4687
PubMed: 27626375
DOI: 10.1038/NATURE19367