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Magnesium in PDB 5t19: Structure of PTP1B Complexed with N-(3'-(1,1-Dioxido-4-Oxo-1,2,5- Thiadiazolidin-2-Yl)-4'-Methyl-[1,1'-Biphenyl]-4-Yl)AcetamideEnzymatic activity of Structure of PTP1B Complexed with N-(3'-(1,1-Dioxido-4-Oxo-1,2,5- Thiadiazolidin-2-Yl)-4'-Methyl-[1,1'-Biphenyl]-4-Yl)Acetamide
All present enzymatic activity of Structure of PTP1B Complexed with N-(3'-(1,1-Dioxido-4-Oxo-1,2,5- Thiadiazolidin-2-Yl)-4'-Methyl-[1,1'-Biphenyl]-4-Yl)Acetamide:
3.1.3.48; Protein crystallography data
The structure of Structure of PTP1B Complexed with N-(3'-(1,1-Dioxido-4-Oxo-1,2,5- Thiadiazolidin-2-Yl)-4'-Methyl-[1,1'-Biphenyl]-4-Yl)Acetamide, PDB code: 5t19
was solved by
A.R.Laciak,
J.J.Tanner,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5t19:
The structure of Structure of PTP1B Complexed with N-(3'-(1,1-Dioxido-4-Oxo-1,2,5- Thiadiazolidin-2-Yl)-4'-Methyl-[1,1'-Biphenyl]-4-Yl)Acetamide also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Structure of PTP1B Complexed with N-(3'-(1,1-Dioxido-4-Oxo-1,2,5- Thiadiazolidin-2-Yl)-4'-Methyl-[1,1'-Biphenyl]-4-Yl)Acetamide
(pdb code 5t19). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Structure of PTP1B Complexed with N-(3'-(1,1-Dioxido-4-Oxo-1,2,5- Thiadiazolidin-2-Yl)-4'-Methyl-[1,1'-Biphenyl]-4-Yl)Acetamide, PDB code: 5t19: Magnesium binding site 1 out of 1 in 5t19Go back to Magnesium Binding Sites List in 5t19
Magnesium binding site 1 out
of 1 in the Structure of PTP1B Complexed with N-(3'-(1,1-Dioxido-4-Oxo-1,2,5- Thiadiazolidin-2-Yl)-4'-Methyl-[1,1'-Biphenyl]-4-Yl)Acetamide
Mono view Stereo pair view
Reference:
P.Punthasee,
A.R.Laciak,
A.H.Cummings,
K.V.Ruddraraju,
S.M.Lewis,
R.Hillebrand,
H.Singh,
J.J.Tanner,
K.S.Gates.
Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) By An Inhibitor-Electrophile Conjugate. Biochemistry V. 56 2051 2017.
Page generated: Mon Dec 14 21:11:08 2020
ISSN: ISSN 1520-4995 PubMed: 28345882 DOI: 10.1021/ACS.BIOCHEM.7B00151 |
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