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Atomistry » Magnesium » PDB 6bcr-6bqz » 6bky | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Magnesium » PDB 6bcr-6bqz » 6bky » |
Magnesium in PDB 6bky: Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2Enzymatic activity of Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2
All present enzymatic activity of Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2:
1.1.1.42; Protein crystallography data
The structure of Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2, PDB code: 6bky
was solved by
C.G.Jakob,
W.Qiu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6bky:
The structure of Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2 also contains other interesting chemical elements:
Magnesium Binding Sites:
The binding sites of Magnesium atom in the Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2
(pdb code 6bky). This binding sites where shown within
5.0 Angstroms radius around Magnesium atom.
In total 4 binding sites of Magnesium where determined in the Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2, PDB code: 6bky: Jump to Magnesium binding site number: 1; 2; 3; 4; Magnesium binding site 1 out of 4 in 6bkyGo back to Magnesium Binding Sites List in 6bky
Magnesium binding site 1 out
of 4 in the Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2
Mono view Stereo pair view
Magnesium binding site 2 out of 4 in 6bkyGo back to Magnesium Binding Sites List in 6bky
Magnesium binding site 2 out
of 4 in the Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2
Mono view Stereo pair view
Magnesium binding site 3 out of 4 in 6bkyGo back to Magnesium Binding Sites List in 6bky
Magnesium binding site 3 out
of 4 in the Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2
Mono view Stereo pair view
Magnesium binding site 4 out of 4 in 6bkyGo back to Magnesium Binding Sites List in 6bky
Magnesium binding site 4 out
of 4 in the Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with CMPD2
Mono view Stereo pair view
Reference:
C.G.Jakob,
A.K.Upadhyay,
P.L.Donner,
E.Nicholl,
S.N.Addo,
W.Qiu,
C.Ling,
S.M.Gopalakrishnan,
M.Torrent,
S.P.Cepa,
J.Shanley,
A.R.Shoemaker,
C.C.Sun,
A.Vasudevan,
K.R.Woller,
J.B.Shotwell,
B.Shaw,
Z.Bian,
J.E.Hutti.
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of HIS315. J. Med. Chem. V. 61 6647 2018.
Page generated: Mon Sep 30 19:46:55 2024
ISSN: ISSN 1520-4804 PubMed: 30004704 DOI: 10.1021/ACS.JMEDCHEM.8B00305 |
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