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Magnesium in PDB 6uso: Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna

Enzymatic activity of Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna

All present enzymatic activity of Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna:
2.7.7.49;

Protein crystallography data

The structure of Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna, PDB code: 6uso was solved by M.A.Schaich, B.D.Freudenthal, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.45 / 2.54
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 101.188, 101.188, 169.321, 90.00, 90.00, 120.00
R / Rfree (%) 24 / 26.5

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna (pdb code 6uso). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 5 binding sites of Magnesium where determined in the Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna, PDB code: 6uso:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5;

Magnesium binding site 1 out of 5 in 6uso

Go back to Magnesium Binding Sites List in 6uso
Magnesium binding site 1 out of 5 in the Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg601

b:90.3
occ:1.00
 OD2 A:ASP251 2.5 70.6 1.0
CG A:ASP251 3.2 75.9 1.0
OD1 A:ASP251 3.3 83.8 1.0
OD2 A:ASP343 3.5 69.8 1.0
O3' E:DA15 3.8 71.0 1.0
CG A:ASP343 3.9 66.6 1.0
O A:ILE252 4.0 67.8 1.0
OD1 A:ASP343 4.1 62.1 1.0
OD1 A:ASP344 4.2 75.5 1.0
O A:HOH706 4.5 55.9 1.0
CB A:ASP251 4.7 66.1 1.0
ND2 A:ASN369 4.7 64.3 1.0
CB A:ASP343 4.9 60.6 1.0

Magnesium binding site 2 out of 5 in 6uso

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Magnesium binding site 2 out of 5 in the Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mg101

b:81.2
occ:1.00
 OP2 F:C5 2.6 78.8 1.0
O F:HOH207 2.8 85.3 1.0
O5' F:A4 3.1 76.7 1.0
OP1 F:A4 3.3 78.0 1.0
P F:A4 3.4 82.2 1.0
OP2 F:A4 3.4 88.1 1.0
C5' F:A4 3.9 76.2 1.0
P F:C5 4.0 87.3 1.0
C3' F:A4 4.3 81.4 1.0
O3' F:A4 4.4 80.2 1.0
C4' F:A4 4.7 84.7 1.0
C5 F:C5 4.7 74.3 1.0
O5' F:C5 4.9 82.8 1.0
O3' F:G3 5.0 80.9 1.0
OP1 F:C5 5.0 82.3 1.0

Magnesium binding site 3 out of 5 in 6uso

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Magnesium binding site 3 out of 5 in the Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mg102

b:83.0
occ:1.00
 OP1 F:G3 3.4 68.5 1.0
OP2 F:G3 3.4 80.8 1.0
OP2 F:A4 3.4 88.1 1.0
O5' F:G3 3.4 78.6 1.0
P F:G3 3.5 68.8 1.0
NZ A:LYS210 3.8 80.9 1.0
CE A:LYS210 4.0 91.3 1.0
C5' F:G3 4.1 81.0 1.0
P F:A4 4.6 82.2 1.0
C3' F:G3 5.0 79.6 1.0

Magnesium binding site 4 out of 5 in 6uso

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Magnesium binding site 4 out of 5 in the Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mg103

b:83.0
occ:1.00
 OP2 F:U7 2.6 85.8 1.0
O5' F:C6 2.8 73.7 1.0
OP2 F:C6 2.9 73.7 1.0
P F:C6 3.0 81.6 1.0
OP1 F:C6 3.1 94.1 1.0
C5' F:C6 3.6 69.6 1.0
C3' F:C6 3.6 79.5 1.0
P F:U7 3.8 92.5 1.0
O3' F:C6 3.9 80.7 1.0
C4' F:C6 4.1 78.4 1.0
O3' F:C5 4.6 81.5 1.0
C2' F:C6 4.8 77.2 1.0
OP1 F:U7 4.8 87.8 1.0
O4' F:C6 4.9 83.5 1.0
C5 F:U7 4.9 85.9 1.0
O5' F:U7 5.0 89.2 1.0

Magnesium binding site 5 out of 5 in 6uso

Go back to Magnesium Binding Sites List in 6uso
Magnesium binding site 5 out of 5 in the Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 5 of Telomerase Reverse Transcriptase Prenucleotide Binary Complex, Tert:Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mg104

b:75.4
occ:1.00
 OH A:TYR217 3.6 72.0 1.0
N3 F:G3 3.6 79.5 1.0
N2 F:G3 3.7 71.2 1.0
O4' F:A4 4.0 82.5 1.0
O2' F:G3 4.1 80.3 1.0
C2 F:G3 4.1 76.1 1.0
C1' F:A4 4.3 80.3 1.0
C2' F:G3 4.5 82.0 1.0
O A:GLY314 4.6 55.9 1.0
C A:GLY314 4.7 57.2 1.0
C1' F:G3 4.8 82.7 1.0
CA A:GLY314 4.8 48.6 1.0
C4 F:G3 4.8 79.4 1.0
CZ A:TYR217 4.9 62.9 1.0

Reference:

M.A.Schaich, S.L.Sanford, G.Welfer, T.H.Khoang, S.A.Johnson, P.L.Opresko, B.D.Freudenthal. Telomerase Reverse Transcriptase Binary Complex, Tert:Dna To Be Published.
Page generated: Wed Aug 13 18:41:22 2025

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