Magnesium in PDB 8srh: Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State

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>>> Page 1 <<< Page 2, Binding sites: 11 - 16;

Binding sites:

The binding sites of Magnesium atom in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State (pdb code 8srh). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 16 binding sites of Magnesium where determined in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State, PDB code: 8srh:
Jump to Magnesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Magnesium binding site 1 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1702 b:111.5 occ:1.00 OE1 A:GLN853 2.5 144.2 1.0 OE2 A:GLU850 2.7 145.7 1.0 OD2 A:ASP872 3.0 130.5 1.0 NE2 A:GLN853 3.1 144.2 1.0 CD A:GLN853 3.2 144.2 1.0 OD1 A:ASN869 3.2 124.6 1.0 OE1 A:GLU850 3.4 145.7 1.0 CD A:GLU850 3.4 145.7 1.0 CG A:ASP872 4.2 130.5 1.0 CG A:ASN869 4.4 124.6 1.0 CG A:GLN853 4.6 144.2 1.0 NH2 A:ARG913 4.7 97.1 1.0 OD1 A:ASP872 4.8 130.5 1.0 CG A:GLU850 4.8 145.7 1.0

Magnesium binding site 2 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1703 b:158.8 occ:1.00 O1A A:APR1706 2.2 166.8 1.0 O2B A:APR1706 2.2 166.8 1.0 MG A:MG1704 2.4 150.2 1.0 CB A:ASP1460 3.3 169.5 1.0 PA A:APR1706 3.4 166.8 1.0 PB A:APR1706 3.5 166.8 1.0 O A:GLY1370 3.7 165.3 1.0 O5' A:APR1706 3.8 166.8 1.0 O3A A:APR1706 3.8 166.8 1.0 O5D A:APR1706 4.2 166.8 1.0 CB A:GLU1390 4.3 183.8 1.0 CA A:ASP1460 4.4 169.5 1.0 O A:ASP1460 4.6 169.5 1.0 N A:ASP1460 4.6 169.5 1.0 C A:ASP1460 4.7 169.5 1.0 O2A A:APR1706 4.7 166.8 1.0 O1B A:APR1706 4.8 166.8 1.0 MG A:MG1705 4.8 157.2 1.0 C A:GLY1370 4.8 165.3 1.0

Magnesium binding site 3 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 3 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1704 b:150.2 occ:1.00 O1A A:APR1706 2.2 166.8 1.0 MG A:MG1703 2.4 158.8 1.0 MG A:MG1705 3.0 157.2 1.0 PA A:APR1706 3.3 166.8 1.0 O5' A:APR1706 3.3 166.8 1.0 CB A:ASP1460 3.9 169.5 1.0 O2B A:APR1706 4.0 166.8 1.0 O2A A:APR1706 4.2 166.8 1.0 N A:ASP1460 4.4 169.5 1.0 CB A:ASP1459 4.5 176.5 1.0 O3A A:APR1706 4.5 166.8 1.0 C5' A:APR1706 4.7 166.8 1.0 CA A:ASP1460 4.8 169.5 1.0 PB A:APR1706 4.9 166.8 1.0

Magnesium binding site 4 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 4 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg1705 b:157.2 occ:1.00 O2A A:APR1706 2.7 166.8 1.0 MG A:MG1704 3.0 150.2 1.0 PA A:APR1706 3.0 166.8 1.0 O1A A:APR1706 3.1 166.8 1.0 O5' A:APR1706 3.3 166.8 1.0 C5' A:APR1706 4.1 166.8 1.0 C4' A:APR1706 4.5 166.8 1.0 O4' A:APR1706 4.5 166.8 1.0 O3A A:APR1706 4.6 166.8 1.0 MG A:MG1703 4.8 158.8 1.0 O A:PHE1372 5.0 170.8 1.0

Magnesium binding site 5 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 5 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1702 b:111.5 occ:1.00 OE1 B:GLN853 2.5 144.2 1.0 OE2 B:GLU850 2.7 145.7 1.0 OD2 B:ASP872 3.0 130.5 1.0 NE2 B:GLN853 3.1 144.2 1.0 CD B:GLN853 3.2 144.2 1.0 OD1 B:ASN869 3.2 124.6 1.0 OE1 B:GLU850 3.4 145.7 1.0 CD B:GLU850 3.4 145.7 1.0 CG B:ASP872 4.2 130.5 1.0 CG B:ASN869 4.4 124.6 1.0 CG B:GLN853 4.6 144.2 1.0 NH2 B:ARG913 4.7 97.1 1.0 OD1 B:ASP872 4.8 130.5 1.0 CG B:GLU850 4.8 145.7 1.0

Magnesium binding site 6 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 6 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1703 b:158.8 occ:1.00 O1A B:APR1706 2.2 166.8 1.0 O2B B:APR1706 2.2 166.8 1.0 MG B:MG1704 2.4 150.2 1.0 CB B:ASP1460 3.3 169.5 1.0 PA B:APR1706 3.4 166.8 1.0 PB B:APR1706 3.5 166.8 1.0 O B:GLY1370 3.7 165.3 1.0 O5' B:APR1706 3.8 166.8 1.0 O3A B:APR1706 3.8 166.8 1.0 O5D B:APR1706 4.2 166.8 1.0 CB B:GLU1390 4.3 183.8 1.0 CA B:ASP1460 4.4 169.5 1.0 O B:ASP1460 4.6 169.5 1.0 N B:ASP1460 4.6 169.5 1.0 C B:ASP1460 4.7 169.5 1.0 O2A B:APR1706 4.7 166.8 1.0 O1B B:APR1706 4.8 166.8 1.0 MG B:MG1705 4.8 157.2 1.0 C B:GLY1370 4.8 165.3 1.0

Magnesium binding site 7 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 7 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1704 b:150.2 occ:1.00 O1A B:APR1706 2.2 166.8 1.0 MG B:MG1703 2.4 158.8 1.0 MG B:MG1705 3.0 157.2 1.0 PA B:APR1706 3.3 166.8 1.0 O5' B:APR1706 3.3 166.8 1.0 CB B:ASP1460 3.9 169.5 1.0 O2B B:APR1706 4.0 166.8 1.0 O2A B:APR1706 4.2 166.8 1.0 N B:ASP1460 4.4 169.5 1.0 CB B:ASP1459 4.5 176.5 1.0 O3A B:APR1706 4.5 166.8 1.0 C5' B:APR1706 4.7 166.8 1.0 CA B:ASP1460 4.8 169.5 1.0 PB B:APR1706 4.9 166.8 1.0

Magnesium binding site 8 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 8 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg1705 b:157.2 occ:1.00 O2A B:APR1706 2.7 166.8 1.0 MG B:MG1704 3.0 150.2 1.0 PA B:APR1706 3.0 166.8 1.0 O1A B:APR1706 3.1 166.8 1.0 O5' B:APR1706 3.3 166.8 1.0 C5' B:APR1706 4.1 166.8 1.0 C4' B:APR1706 4.5 166.8 1.0 O4' B:APR1706 4.5 166.8 1.0 O3A B:APR1706 4.6 166.8 1.0 MG B:MG1703 4.8 158.8 1.0 O B:PHE1372 5.0 170.8 1.0

Magnesium binding site 9 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 9 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg1702 b:111.5 occ:1.00 OE1 C:GLN853 2.5 144.2 1.0 OE2 C:GLU850 2.7 145.7 1.0 OD2 C:ASP872 3.0 130.5 1.0 NE2 C:GLN853 3.1 144.2 1.0 CD C:GLN853 3.2 144.2 1.0 OD1 C:ASN869 3.2 124.6 1.0 OE1 C:GLU850 3.4 145.7 1.0 CD C:GLU850 3.4 145.7 1.0 CG C:ASP872 4.2 130.5 1.0 CG C:ASN869 4.4 124.6 1.0 CG C:GLN853 4.6 144.2 1.0 NH2 C:ARG913 4.7 97.1 1.0 OD1 C:ASP872 4.8 130.5 1.0 CG C:GLU850 4.8 145.7 1.0

Magnesium binding site 10 out of 16 in the Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 10 of Cryo-Em Structure of TRPM2 Chanzyme (E1114A) in the Presence of Magnesium and Adp-Ribose, Open State within 5.0Å range: probe atom residue distance (Å) B Occ C:Mg1703 b:158.8 occ:1.00 O1A C:APR1706 2.2 166.8 1.0 O2B C:APR1706 2.2 166.8 1.0 MG C:MG1704 2.4 150.2 1.0 CB C:ASP1460 3.3 169.5 1.0 PA C:APR1706 3.4 166.8 1.0 PB C:APR1706 3.5 166.8 1.0 O C:GLY1370 3.7 165.3 1.0 O5' C:APR1706 3.8 166.8 1.0 O3A C:APR1706 3.8 166.8 1.0 O5D C:APR1706 4.2 166.8 1.0 CB C:GLU1390 4.3 183.8 1.0 CA C:ASP1460 4.4 169.5 1.0 O C:ASP1460 4.6 169.5 1.0 N C:ASP1460 4.6 169.5 1.0 C C:ASP1460 4.7 169.5 1.0 O2A C:APR1706 4.7 166.8 1.0 O1B C:APR1706 4.8 166.8 1.0 MG C:MG1705 4.8 157.2 1.0 C C:GLY1370 4.8 165.3 1.0

Y.Huang, W.Lu, J.Du. Coupling Enzymatic Activity and Gating in An Ancient Trpm Chanzyme and Its Molecular Evolution To Be Published.