Atomistry » Magnesium » PDB 1ofh-1oyj » 1oiy
Atomistry »
  Magnesium »
    PDB 1ofh-1oyj »
      1oiy »

Magnesium in PDB 1oiy: Structure of Human THR160-Phospho CDK2/Cyclin A Complexed with A 6-Cyclohexylmethyloxy-2-Anilino-Purine Inhibitor

Enzymatic activity of Structure of Human THR160-Phospho CDK2/Cyclin A Complexed with A 6-Cyclohexylmethyloxy-2-Anilino-Purine Inhibitor

All present enzymatic activity of Structure of Human THR160-Phospho CDK2/Cyclin A Complexed with A 6-Cyclohexylmethyloxy-2-Anilino-Purine Inhibitor:
2.7.1.37;

Protein crystallography data

The structure of Structure of Human THR160-Phospho CDK2/Cyclin A Complexed with A 6-Cyclohexylmethyloxy-2-Anilino-Purine Inhibitor, PDB code: 1oiy was solved by D.J.Pratt, J.A.Endicott, M.E.M.Noble, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 100.00 / 2.4
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 73.997, 134.872, 147.865, 90.00, 90.00, 90.00
R / Rfree (%) 24.4 / 30.9

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Structure of Human THR160-Phospho CDK2/Cyclin A Complexed with A 6-Cyclohexylmethyloxy-2-Anilino-Purine Inhibitor (pdb code 1oiy). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Structure of Human THR160-Phospho CDK2/Cyclin A Complexed with A 6-Cyclohexylmethyloxy-2-Anilino-Purine Inhibitor, PDB code: 1oiy:

Magnesium binding site 1 out of 1 in 1oiy

Go back to Magnesium Binding Sites List in 1oiy
Magnesium binding site 1 out of 1 in the Structure of Human THR160-Phospho CDK2/Cyclin A Complexed with A 6-Cyclohexylmethyloxy-2-Anilino-Purine Inhibitor


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Structure of Human THR160-Phospho CDK2/Cyclin A Complexed with A 6-Cyclohexylmethyloxy-2-Anilino-Purine Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg1433

b:19.8
occ:1.00
 O B:GLN203 2.3 37.0 1.0
O B:MET200 2.6 37.7 1.0
O B:ILE206 2.6 32.9 1.0
O B:HOH2004 2.9 47.2 1.0
O B:HOH2025 3.0 25.1 1.0
C B:GLN203 3.5 37.0 1.0
C B:MET200 3.8 37.9 1.0
C B:ILE206 3.9 32.3 1.0
CB B:GLN203 4.0 36.8 1.0
CA B:GLN203 4.1 37.3 1.0
N B:GLN203 4.2 38.1 1.0
CG B:MET200 4.3 35.2 1.0
O B:PRO204 4.4 36.4 1.0
N B:PRO204 4.6 37.0 1.0
N B:ILE206 4.6 32.7 1.0
C B:PRO204 4.6 36.2 1.0
N B:LYS201 4.6 38.8 1.0
CA B:THR207 4.6 31.3 1.0
O B:LYS201 4.6 40.9 1.0
CA B:LYS201 4.7 39.9 1.0
CA B:MET200 4.7 37.0 1.0
C B:LYS201 4.7 40.1 1.0
N B:THR207 4.7 32.1 1.0
CG2 B:THR207 4.7 31.0 1.0
SD B:MET200 4.8 35.4 1.0
CA B:ILE206 4.8 32.3 1.0
CA B:PRO204 4.9 37.0 1.0
CB B:MET200 4.9 37.0 1.0

Reference:

I.R.Hardcastle, C.E.Arris, J.Bentley, F.T.Boyle, Y.Chen, N.J.Curtin, J.A.Endicott, A.E.Gibson, B.T.Golding, R.J.Griffin, P.Jewsbury, J.Menyerol, V.Mesguiche, D.R.Newell, M.E.M.Noble, D.J.Pratt, L.-Z.Wang, H.J.Whitfield. N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 J.Med.Chem. V. 47 3710 2004.
ISSN: ISSN 0022-2623
PubMed: 15239650
DOI: 10.1021/JM0311442
Page generated: Sun Aug 10 02:11:06 2025

Last articles

Mg in 1VQ4
Mg in 1VPA
Mg in 1VPE
Mg in 1VOM
Mg in 1VMA
Mg in 1VMK
Mg in 1VM9
Mg in 1VCR
Mg in 1VLB
Mg in 1VKP
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy