Atomistry » Magnesium » PDB 3oto-3p0x » 3ozt
Atomistry »
  Magnesium »
    PDB 3oto-3p0x »
      3ozt »

Magnesium in PDB 3ozt: Rat Catechol O-Methyltransferase in Complex with A Catechol-Type, 4- Oxo-Pyridinyl-Containing Inhibitor - Humanized Form

Enzymatic activity of Rat Catechol O-Methyltransferase in Complex with A Catechol-Type, 4- Oxo-Pyridinyl-Containing Inhibitor - Humanized Form

All present enzymatic activity of Rat Catechol O-Methyltransferase in Complex with A Catechol-Type, 4- Oxo-Pyridinyl-Containing Inhibitor - Humanized Form:
2.1.1.6;

Protein crystallography data

The structure of Rat Catechol O-Methyltransferase in Complex with A Catechol-Type, 4- Oxo-Pyridinyl-Containing Inhibitor - Humanized Form, PDB code: 3ozt was solved by A.Ehler, D.Schlatter, M.Stihle, J.Benz, M.G.Rudolph, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.64 / 1.48
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 50.905, 50.905, 168.198, 90.00, 90.00, 120.00
R / Rfree (%) 18.7 / 22.4

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Rat Catechol O-Methyltransferase in Complex with A Catechol-Type, 4- Oxo-Pyridinyl-Containing Inhibitor - Humanized Form (pdb code 3ozt). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Rat Catechol O-Methyltransferase in Complex with A Catechol-Type, 4- Oxo-Pyridinyl-Containing Inhibitor - Humanized Form, PDB code: 3ozt:

Magnesium binding site 1 out of 1 in 3ozt

Go back to Magnesium Binding Sites List in 3ozt
Magnesium binding site 1 out of 1 in the Rat Catechol O-Methyltransferase in Complex with A Catechol-Type, 4- Oxo-Pyridinyl-Containing Inhibitor - Humanized Form


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Rat Catechol O-Methyltransferase in Complex with A Catechol-Type, 4- Oxo-Pyridinyl-Containing Inhibitor - Humanized Form within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg222

b:21.8
occ:1.00
 OD1 A:ASP141 1.9 19.9 1.0
O A:HOH236 2.0 22.8 1.0
OD2 A:ASP169 2.1 22.6 1.0
OD1 A:ASN170 2.1 19.7 1.0
O21 A:OZZ223 2.2 22.2 1.0
O22 A:OZZ223 2.2 24.3 1.0
C15 A:OZZ223 2.9 21.1 1.0
CG A:ASP141 3.0 19.1 1.0
C16 A:OZZ223 3.0 20.6 1.0
CG A:ASN170 3.1 21.8 1.0
CG A:ASP169 3.2 23.7 1.0
OD2 A:ASP141 3.3 22.4 1.0
ND2 A:ASN170 3.5 20.9 1.0
CB A:ASP169 3.8 21.2 1.0
NZ A:LYS144 3.8 20.3 1.0
O A:HOH377 3.9 44.1 1.0
OD1 A:ASP169 4.2 22.3 1.0
OE2 A:GLU199 4.2 24.8 1.0
C14 A:OZZ223 4.3 23.5 1.0
O A:MET40 4.3 25.4 1.0
C17 A:OZZ223 4.3 22.7 1.0
CB A:ASP141 4.4 19.8 1.0
CB A:ASN170 4.5 21.3 1.0
CG2 A:VAL42 4.7 22.0 0.5
CE A:LYS144 4.7 22.1 1.0
O A:ASP141 4.7 23.1 1.0
NZ A:LYS46 4.8 21.5 1.0
N12 A:OZZ223 4.8 22.7 1.0
OE1 A:GLU199 4.9 26.5 1.0
CA A:ASP141 4.9 17.0 1.0
CD A:GLU199 5.0 26.4 1.0

Reference:

M.Ellermann, R.Paulini, R.Jakob-Roetne, C.Lerner, E.Borroni, D.Roth, A.Ehler, W.B.Schweizer, D.Schlatter, M.G.Rudolph, F.Diederich. Molecular Recognition at the Active Site of Catechol-O-Methyltransferase (Comt): Adenine Replacements in Bisubstrate Inhibitors Chemistry V. 17 6369 2011.
ISSN: ISSN 0947-6539
PubMed: 21538606
DOI: 10.1002/CHEM.201003648
Page generated: Thu Aug 15 09:01:15 2024

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy