Magnesium in PDB 7krj: The Gr-Maturation Complex: Glucocorticoid Receptor in Complex with HSP90 and Co-Chaperone P23

All present enzymatic activity of The Gr-Maturation Complex: Glucocorticoid Receptor in Complex with HSP90 and Co-Chaperone P23:
5.3.99.3;

The structure of The Gr-Maturation Complex: Glucocorticoid Receptor in Complex with HSP90 and Co-Chaperone P23 also contains other interesting chemical elements:

Fluorine

(F)

1 atom

The binding sites of Magnesium atom in the The Gr-Maturation Complex: Glucocorticoid Receptor in Complex with HSP90 and Co-Chaperone P23 (pdb code 7krj). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the The Gr-Maturation Complex: Glucocorticoid Receptor in Complex with HSP90 and Co-Chaperone P23, PDB code: 7krj:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the The Gr-Maturation Complex: Glucocorticoid Receptor in Complex with HSP90 and Co-Chaperone P23


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of The Gr-Maturation Complex: Glucocorticoid Receptor in Complex with HSP90 and Co-Chaperone P23 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg802 b:48.4 occ:1.00 O1B A:ATP801 1.8 45.2 1.0 O2A A:ATP801 1.8 45.9 1.0 OD1 A:ASN51 2.0 48.5 1.0 PB A:ATP801 2.9 42.4 1.0 O1G A:ATP801 2.9 40.2 1.0 PA A:ATP801 2.9 41.8 1.0 O3A A:ATP801 3.1 40.0 1.0 CG A:ASN51 3.1 46.6 1.0 HD21 A:ASN51 3.6 57.9 1.0 O5' A:ATP801 3.7 42.5 1.0 O3B A:ATP801 3.7 39.1 1.0 ND2 A:ASN51 3.8 48.2 1.0 PG A:ATP801 3.9 31.1 1.0 HA A:ASN51 4.0 54.3 1.0 HA3 A:GLY137 4.1 50.4 1.0 O2B A:ATP801 4.1 41.2 1.0 OE1 A:GLU47 4.1 56.1 1.0 O1A A:ATP801 4.2 43.3 1.0 CB A:ASN51 4.3 46.7 1.0 H3' A:ATP801 4.3 52.5 1.0 HA3 A:GLY132 4.5 55.6 1.0 O A:GLU47 4.5 45.2 1.0 CA A:ASN51 4.5 45.2 1.0 O2G A:ATP801 4.5 30.6 1.0 H A:PHE138 4.6 50.5 1.0 H A:GLY137 4.7 49.0 1.0 H A:ASN51 4.7 53.0 1.0 HB3 A:GLU47 4.7 56.2 1.0 O A:ILE131 4.7 58.8 1.0 HB2 A:SER50 4.7 52.5 1.0 N A:ASN51 4.7 44.1 1.0 HB3 A:ASN51 4.7 56.0 1.0 HD22 A:ASN51 4.8 57.9 1.0 HA2 A:GLY132 4.8 55.6 1.0 CA A:GLY137 4.9 42.0 1.0 N A:PHE138 5.0 42.1 1.0

Magnesium binding site 2 out of 2 in the The Gr-Maturation Complex: Glucocorticoid Receptor in Complex with HSP90 and Co-Chaperone P23


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of The Gr-Maturation Complex: Glucocorticoid Receptor in Complex with HSP90 and Co-Chaperone P23 within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg802 b:52.8 occ:1.00 O1B B:ATP801 1.8 45.9 1.0 O2A B:ATP801 1.8 47.8 1.0 OD1 B:ASN51 2.0 49.2 1.0 O1G B:ATP801 2.8 44.5 1.0 PB B:ATP801 2.8 43.5 1.0 PA B:ATP801 2.9 43.1 1.0 O3A B:ATP801 3.1 41.9 1.0 CG B:ASN51 3.1 48.3 1.0 HD21 B:ASN51 3.6 61.6 1.0 O5' B:ATP801 3.6 43.9 1.0 O3B B:ATP801 3.7 41.8 1.0 PG B:ATP801 3.8 26.5 1.0 ND2 B:ASN51 3.8 51.4 1.0 HA B:ASN51 4.0 56.0 1.0 O2B B:ATP801 4.1 42.7 1.0 HA3 B:GLY137 4.2 52.2 1.0 OE1 B:GLU47 4.2 59.6 1.0 O1A B:ATP801 4.2 44.2 1.0 CB B:ASN51 4.3 48.7 1.0 HA2 B:GLY132 4.3 61.1 1.0 H3' B:ATP801 4.4 54.6 1.0 O2G B:ATP801 4.4 32.9 1.0 O B:GLU47 4.5 47.6 1.0 CA B:ASN51 4.5 46.6 1.0 HA3 B:GLY132 4.5 61.1 1.0 H B:ASN51 4.6 55.9 1.0 H B:PHE138 4.7 52.8 1.0 N B:ASN51 4.7 46.5 1.0 HB2 B:SER50 4.7 55.5 1.0 HB3 B:ASN51 4.7 58.4 1.0 O B:ILE131 4.8 54.9 1.0 HB3 B:GLU47 4.8 58.9 1.0 HD22 B:ASN51 4.8 61.6 1.0 CA B:GLY132 5.0 50.9 1.0

C.M.Noddings, R.Y.Wang, J.L.Johnson, D.A.Agard. Structure of HSP90-P23-Gr Reveals the HSP90 Client-Remodelling Mechanism. Nature V. 601 465 2021.
ISSN: ESSN 1476-4687
PubMed: 34937936
DOI: 10.1038/S41586-021-04236-1