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Magnesium in PDB 7qfo: Human Topoisomerase II Beta Atpase Amppnp

Enzymatic activity of Human Topoisomerase II Beta Atpase Amppnp

All present enzymatic activity of Human Topoisomerase II Beta Atpase Amppnp:
5.6.2.2;

Protein crystallography data

The structure of Human Topoisomerase II Beta Atpase Amppnp, PDB code: 7qfo was solved by E.M.Ling, A.Basle, I.G.Cowell, T.R.Blower, C.A.Austin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 59.41 / 1.90
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 84.021, 84.021, 127.091, 90, 90, 90
R / Rfree (%) 19.3 / 23.2

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Human Topoisomerase II Beta Atpase Amppnp (pdb code 7qfo). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Human Topoisomerase II Beta Atpase Amppnp, PDB code: 7qfo:

Magnesium binding site 1 out of 1 in 7qfo

Go back to Magnesium Binding Sites List in 7qfo
Magnesium binding site 1 out of 1 in the Human Topoisomerase II Beta Atpase Amppnp


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human Topoisomerase II Beta Atpase Amppnp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg503

b:31.8
occ:1.00
O3G A:ANP502 2.0 27.4 1.0
O1B A:ANP502 2.1 28.7 1.0
OD1 A:ASN107 2.1 30.1 1.0
O2A A:ANP502 2.1 33.6 1.0
O A:HOH664 2.2 30.2 1.0
O A:HOH601 2.2 29.6 1.0
PB A:ANP502 3.1 32.2 1.0
CG A:ASN107 3.1 28.3 1.0
HD21 A:ASN107 3.1 30.0 1.0
PA A:ANP502 3.3 31.2 1.0
PG A:ANP502 3.3 29.6 1.0
O3A A:ANP502 3.4 30.0 1.0
ND2 A:ASN107 3.4 30.8 1.0
N3B A:ANP502 3.5 29.3 1.0
HA3 A:GLY182 3.6 33.1 1.0
HA2 A:GLY177 3.7 32.1 1.0
HA3 A:GLY177 3.9 32.1 1.0
O A:HOH652 4.0 30.6 1.0
O5' A:ANP502 4.0 31.2 1.0
H A:GLY182 4.1 31.9 1.0
O A:HOH647 4.1 36.9 1.0
OE2 A:GLU103 4.2 33.6 1.0
O A:GLU103 4.2 30.3 1.0
O2G A:ANP502 4.2 30.7 1.0
HA A:ASN107 4.3 29.5 1.0
CA A:GLY177 4.3 32.5 1.0
HD22 A:ASN107 4.3 30.0 1.0
HNB1 A:ANP502 4.3 30.0 1.0
H A:ALA183 4.3 31.8 1.0
CB A:ASN107 4.4 27.7 1.0
CA A:GLY182 4.4 33.2 1.0
O2B A:ANP502 4.4 32.7 1.0
O1G A:ANP502 4.5 30.0 1.0
O1A A:ANP502 4.5 29.4 1.0
H3' A:ANP502 4.5 31.9 1.0
N A:GLY182 4.6 32.8 1.0
HB3 A:GLU103 4.6 30.4 1.0
OD2 A:ASP110 4.7 34.2 1.0
CA A:ASN107 4.7 29.6 1.0
H A:ASN107 4.7 28.9 1.0
HZ2 A:LYS394 4.7 37.9 1.0
HG11 A:VAL106 4.7 30.9 1.0
HZ1 A:LYS394 4.8 37.9 1.0
N A:ALA183 4.9 31.2 1.0
N A:ASN107 4.9 28.4 1.0
HB2 A:ASN107 4.9 28.3 1.0
HA A:GLU103 5.0 30.7 1.0
HB3 A:ASN107 5.0 28.3 1.0

Reference:

E.M.Ling, A.Basle, I.G.Cowell, B.Van Den Berg, T.R.Blower, C.A.Austin. A Comprehensive Structural Analysis of the Atpase Domain of Human Dna Topoisomerase II Beta Bound to Amppnp, Adp, and the Bisdioxopiperazine, ICRF193. Structure V. 30 1129 2022.
ISSN: ISSN 0969-2126
PubMed: 35660158
DOI: 10.1016/J.STR.2022.05.009
Page generated: Thu Oct 3 05:06:00 2024

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