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Magnesium in PDB 1eye: 1.7 Angstrom Resolution Crystal Structure of 6-Hydroxymethyl-7,8- Dihydropteroate Synthase (Dhps) From Mycobacterium Tuberculosis in Complex with 6-Hydroxymethylpterin Monophosphate

Enzymatic activity of 1.7 Angstrom Resolution Crystal Structure of 6-Hydroxymethyl-7,8- Dihydropteroate Synthase (Dhps) From Mycobacterium Tuberculosis in Complex with 6-Hydroxymethylpterin Monophosphate

All present enzymatic activity of 1.7 Angstrom Resolution Crystal Structure of 6-Hydroxymethyl-7,8- Dihydropteroate Synthase (Dhps) From Mycobacterium Tuberculosis in Complex with 6-Hydroxymethylpterin Monophosphate:
2.5.1.15;

Protein crystallography data

The structure of 1.7 Angstrom Resolution Crystal Structure of 6-Hydroxymethyl-7,8- Dihydropteroate Synthase (Dhps) From Mycobacterium Tuberculosis in Complex with 6-Hydroxymethylpterin Monophosphate, PDB code: 1eye was solved by A.M.Baca, R.Sirawaraporn, S.Turley, W.Sirawaraporn, W.G.J.Hol, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.70
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 62.900, 62.900, 121.400, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Magnesium Binding Sites:

The binding sites of Magnesium atom in the 1.7 Angstrom Resolution Crystal Structure of 6-Hydroxymethyl-7,8- Dihydropteroate Synthase (Dhps) From Mycobacterium Tuberculosis in Complex with 6-Hydroxymethylpterin Monophosphate (pdb code 1eye). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the 1.7 Angstrom Resolution Crystal Structure of 6-Hydroxymethyl-7,8- Dihydropteroate Synthase (Dhps) From Mycobacterium Tuberculosis in Complex with 6-Hydroxymethylpterin Monophosphate, PDB code: 1eye:

Magnesium binding site 1 out of 1 in 1eye

Go back to Magnesium Binding Sites List in 1eye
Magnesium binding site 1 out of 1 in the 1.7 Angstrom Resolution Crystal Structure of 6-Hydroxymethyl-7,8- Dihydropteroate Synthase (Dhps) From Mycobacterium Tuberculosis in Complex with 6-Hydroxymethylpterin Monophosphate


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of 1.7 Angstrom Resolution Crystal Structure of 6-Hydroxymethyl-7,8- Dihydropteroate Synthase (Dhps) From Mycobacterium Tuberculosis in Complex with 6-Hydroxymethylpterin Monophosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mg300

b:45.6
occ:1.00
 OD1 A:ASN13 1.9 79.5 1.0
O1P A:PMM301 2.2 24.6 1.0
NE2 A:HIS255 2.9 16.8 1.0
CG A:ASN13 3.2 57.5 1.0
N A:GLY22 3.3 24.1 1.0
O A:HOH308 3.3 40.2 1.0
PA A:PMM301 3.4 20.0 1.0
CD2 A:HIS255 3.4 16.9 1.0
O3P A:PMM301 3.7 24.4 1.0
CB A:ASP21 3.7 14.4 1.0
O A:GLY22 3.8 50.4 1.0
OG A:SER20 3.8 29.1 1.0
N A:ASP21 3.9 16.6 1.0
C A:ASP21 3.9 26.3 1.0
O A:HOH306 3.9 42.1 1.0
CG1 A:VAL11 3.9 10.2 1.0
ND2 A:ASN13 4.0 84.7 1.0
CA A:GLY22 4.0 24.9 1.0
O2P A:PMM301 4.0 30.6 1.0
CA A:ASP21 4.1 15.3 1.0
CE1 A:HIS255 4.1 15.8 1.0
C A:GLY22 4.2 47.4 1.0
CB A:ASN13 4.2 29.8 1.0
O A:HOH309 4.3 39.9 1.0
O A:HOH307 4.4 55.7 1.0
O10 A:PMM301 4.6 27.0 1.0
O A:ASP21 4.7 23.1 1.0
CG A:HIS255 4.7 14.2 1.0
CG A:ASP21 4.9 28.2 1.0
C A:SER20 4.9 24.5 1.0

Reference:

A.M.Baca, R.Sirawaraporn, S.Turley, W.Sirawaraporn, W.G.Hol. Crystal Structure of Mycobacterium Tuberculosis 7,8-Dihydropteroate Synthase in Complex with Pterin Monophosphate: New Insight Into the Enzymatic Mechanism and Sulfa-Drug Action. J.Mol.Biol. V. 302 1193 2000.
ISSN: ISSN 0022-2836
PubMed: 11007651
DOI: 10.1006/JMBI.2000.4094
Page generated: Tue Aug 13 03:04:13 2024

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