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Magnesium in PDB 2coi: Crystal Structure of Oxidized Human Cytosolic Branched-Chain Aminotransferase Complexed with Gabapentin

Enzymatic activity of Crystal Structure of Oxidized Human Cytosolic Branched-Chain Aminotransferase Complexed with Gabapentin

All present enzymatic activity of Crystal Structure of Oxidized Human Cytosolic Branched-Chain Aminotransferase Complexed with Gabapentin:
2.6.1.42;

Protein crystallography data

The structure of Crystal Structure of Oxidized Human Cytosolic Branched-Chain Aminotransferase Complexed with Gabapentin, PDB code: 2coi was solved by M.Goto, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.37 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 66.720, 107.690, 110.300, 90.00, 90.00, 90.00
R / Rfree (%) 22.4 / 27.2

Magnesium Binding Sites:

The binding sites of Magnesium atom in the Crystal Structure of Oxidized Human Cytosolic Branched-Chain Aminotransferase Complexed with Gabapentin (pdb code 2coi). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total only one binding site of Magnesium was determined in the Crystal Structure of Oxidized Human Cytosolic Branched-Chain Aminotransferase Complexed with Gabapentin, PDB code: 2coi:

Magnesium binding site 1 out of 1 in 2coi

Go back to Magnesium Binding Sites List in 2coi
Magnesium binding site 1 out of 1 in the Crystal Structure of Oxidized Human Cytosolic Branched-Chain Aminotransferase Complexed with Gabapentin


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Crystal Structure of Oxidized Human Cytosolic Branched-Chain Aminotransferase Complexed with Gabapentin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mg1430

b:31.4
occ:1.00
 OD1 B:ASP133 2.2 18.0 1.0
O B:HOH1746 2.3 27.1 1.0
O B:HOH1745 2.3 36.8 1.0
O B:HOH1748 2.4 27.3 1.0
O B:HOH1477 2.4 23.6 1.0
O B:HOH1747 2.5 29.1 1.0
CG B:ASP133 3.2 21.5 1.0
OD2 B:ASP133 3.4 23.4 1.0
O B:HOH1593 4.1 32.7 1.0
O B:HOH1662 4.3 43.2 1.0
CB B:ASP133 4.6 19.4 1.0
O B:HOH1688 4.6 40.0 1.0
OE1 B:GLU136 4.6 31.7 1.0
OE1 B:GLU135 4.8 36.9 1.0
CB B:GLU135 4.9 28.0 1.0
CD B:GLU135 5.0 38.3 1.0

Reference:

M.Goto, I.Miyahara, K.Hirotsu, M.Conway, N.Yennawar, M.M.Islam, S.M.Hutson. Structural Determinants For Branched-Chain Aminotransferase Isozyme-Specific Inhibition By the Anticonvulsant Drug Gabapentin J.Biol.Chem. V. 280 37246 2005.
ISSN: ISSN 0021-9258
PubMed: 16141215
DOI: 10.1074/JBC.M506486200
Page generated: Sun Aug 10 10:20:14 2025

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