Magnesium in PDB 5npq: Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound

All present enzymatic activity of Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound:
2.3.1.97;

The structure of Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound, PDB code: 5npq was solved by M.Shen, I.Perez-Dorado, R.Fedoryshchak, E.W.Tate, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	88.73 / 2.37
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	79.972, 177.454, 58.244, 90.00, 90.00, 90.00
R / Rfree (%)	19.9 / 26.1

The binding sites of Magnesium atom in the Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound (pdb code 5npq). This binding sites where shown within 5.0 Angstroms radius around Magnesium atom.
In total 2 binding sites of Magnesium where determined in the Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound, PDB code: 5npq:
Jump to Magnesium binding site number: 1; 2;

Magnesium binding site 1 out of 2 in the Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 1 of Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound within 5.0Å range: probe atom residue distance (Å) B Occ A:Mg504 b:38.0 occ:1.00 O A:LEU254 2.7 29.7 1.0 O36 A:94Q503 2.8 33.6 1.0 N A:LYS257 2.8 36.1 1.0 O33 A:94Q503 2.9 31.4 1.0 N A:VAL259 3.2 31.1 1.0 N A:SER256 3.2 35.5 1.0 CB A:VAL259 3.4 33.9 1.0 CG2 A:VAL259 3.4 25.8 1.0 C A:ARG255 3.5 36.9 1.0 N A:ARG258 3.5 33.9 1.0 CA A:LYS257 3.5 30.3 1.0 C A:LYS257 3.5 36.4 1.0 CA A:ARG255 3.6 34.1 1.0 CB A:LYS257 3.7 30.8 1.0 C A:LEU254 3.8 34.6 1.0 CG1 A:VAL250 3.8 31.4 1.0 C A:SER256 3.8 38.0 1.0 O34 A:94Q503 3.9 32.2 1.0 CA A:VAL259 3.9 30.7 1.0 P09 A:94Q503 3.9 37.4 1.0 CA A:SER256 4.0 37.3 1.0 O A:ARG255 4.1 41.1 1.0 P07 A:94Q503 4.1 36.9 1.0 N A:ARG255 4.2 27.6 1.0 C A:ARG258 4.2 34.0 1.0 O A:LYS257 4.3 34.6 1.0 CA A:ARG258 4.3 31.0 1.0 CG A:LYS257 4.4 33.9 1.0 N A:ALA260 4.4 29.7 1.0 O08 A:94Q503 4.4 37.4 1.0 CG2 A:VAL250 4.6 26.4 1.0 CB A:VAL250 4.7 27.5 1.0 C A:VAL259 4.7 26.7 1.0 CG1 A:VAL259 4.8 26.3 1.0 CB A:ARG255 5.0 35.3 1.0 O A:SER256 5.0 37.6 1.0

Magnesium binding site 2 out of 2 in the Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound


Mono view


Stereo pair view

A full contact list of Magnesium with other atoms in the Mg binding site number 2 of Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound within 5.0Å range: probe atom residue distance (Å) B Occ B:Mg504 b:43.8 occ:1.00 O B:LEU254 2.7 43.8 1.0 N B:VAL259 2.8 39.8 1.0 O36 B:94Q503 2.9 36.4 1.0 CG2 B:VAL259 2.9 39.3 1.0 N B:LYS257 3.0 48.6 1.0 CB B:VAL259 3.0 36.9 1.0 O33 B:94Q503 3.1 36.6 1.0 C B:LYS257 3.3 46.3 1.0 CA B:LYS257 3.4 48.9 1.0 N B:ARG258 3.4 46.3 1.0 CB B:LYS257 3.5 46.3 1.0 CA B:VAL259 3.5 40.7 1.0 N B:SER256 3.8 46.0 1.0 C B:ARG258 3.9 40.9 1.0 C B:LEU254 3.9 42.0 1.0 C B:ARG255 3.9 43.8 1.0 O B:LYS257 4.0 44.9 1.0 CG1 B:VAL250 4.1 39.5 1.0 O34 B:94Q503 4.1 45.7 1.0 C B:SER256 4.1 49.4 1.0 CA B:ARG255 4.1 44.6 1.0 P09 B:94Q503 4.2 40.4 1.0 CA B:ARG258 4.2 46.5 1.0 P07 B:94Q503 4.3 29.6 1.0 CG B:LYS257 4.3 46.2 1.0 N B:ALA260 4.3 36.5 1.0 C B:VAL259 4.4 37.0 1.0 CG1 B:VAL259 4.4 34.7 1.0 CA B:SER256 4.4 49.7 1.0 O B:ARG255 4.5 47.6 1.0 N B:ARG255 4.5 37.0 1.0 O08 B:94Q503 4.8 44.8 1.0 CG2 B:VAL250 4.9 29.9 1.0 CB B:VAL250 4.9 38.7 1.0 O06 B:94Q503 5.0 47.6 1.0 O B:ARG258 5.0 35.7 1.0

M.Shen, I.Perez-Dorado, R.Fedoryshchak, E.W.Tate. Human N-Myristoyltransferase 1 (MNT1) with Myristoyl-Coa Analogue X10 Bound. To Be Published.